280487

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 99643..100244 Replicon plasmid pAVS0756-A
Accession NZ_CP124482
Organism Escherichia coli strain AVS0756

Toxin (Protein)


Gene name doc Uniprot ID V0AJ64
Locus tag QJP55_RS24105 Protein ID WP_001216034.1
Coordinates 99864..100244 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag QJP55_RS24100 Protein ID WP_001190712.1
Coordinates 99643..99864 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP55_RS24090 (96624) 96624..97907 - 1284 WP_001617890.1 restriction endonuclease subunit S -
QJP55_RS24095 (97904) 97904..99460 - 1557 WP_001617892.1 type I restriction-modification system subunit M -
QJP55_RS24100 (99643) 99643..99864 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QJP55_RS24105 (99864) 99864..100244 + 381 WP_001216034.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
QJP55_RS24110 (100249) 100249..100428 + 180 WP_001513661.1 hypothetical protein -
QJP55_RS24115 (100456) 100456..100734 + 279 Protein_117 pdcB -
QJP55_RS24120 (100739) 100739..101152 + 414 Protein_118 integrase core domain-containing protein -
QJP55_RS24125 (101102) 101102..101437 - 336 WP_169329198.1 type I deoxyribonuclease HsdR -
QJP55_RS24130 (101647) 101647..102627 - 981 WP_000019407.1 IS5-like element IS5 family transposase -
QJP55_RS24135 (102871) 102871..104274 + 1404 WP_001373486.1 S-methylmethionine permease -
QJP55_RS24140 (104261) 104261..105193 + 933 WP_000081352.1 homocysteine S-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / blaCTX-M-27 - 1..108535 108535


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13615.32 Da        Isoelectric Point: 5.1514

>T280487 WP_001216034.1 NZ_CP124482:99864-100244 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT280487 WP_001190712.1 NZ_CP124482:99643-99864 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0AJ64

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References