280479

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 4168165..4169446 Replicon chromosome
Accession NZ_CP124481
Organism Escherichia coli strain AVS0756

Toxin (Protein)


Gene name sanaT Uniprot ID A0A1X3JHM4
Locus tag QJP55_RS20320 Protein ID WP_001114681.1
Coordinates 4168553..4169446 (+) Length 298 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID V0YCI1
Locus tag QJP55_RS20315 Protein ID WP_000208383.1
Coordinates 4168165..4168560 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP55_RS20270 (4163659) 4163659..4164144 + 486 WP_000849566.1 antirestriction protein -
QJP55_RS20275 (4164160) 4164160..4164636 + 477 WP_001186726.1 RadC family protein -
QJP55_RS20280 (4164699) 4164699..4164920 + 222 WP_000692329.1 DUF987 domain-containing protein -
QJP55_RS20285 (4164939) 4164939..4165583 + 645 WP_000094916.1 hypothetical protein -
QJP55_RS20290 (4165633) 4165633..4166013 + 381 WP_001285598.1 type IV toxin-antitoxin system YeeU family antitoxin -
QJP55_RS20295 (4166090) 4166090..4166467 + 378 WP_000854689.1 TA system toxin CbtA family protein -
QJP55_RS20300 (4166464) 4166464..4166952 + 489 WP_000761699.1 DUF5983 family protein -
QJP55_RS20305 (4166969) 4166969..4167166 + 198 WP_000839293.1 DUF957 domain-containing protein -
QJP55_RS20310 (4167251) 4167251..4168096 + 846 WP_023281696.1 DUF4942 domain-containing protein -
QJP55_RS20315 (4168165) 4168165..4168560 + 396 WP_000208383.1 DUF6088 family protein Antitoxin
QJP55_RS20320 (4168553) 4168553..4169446 + 894 WP_001114681.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QJP55_RS20325 (4169917) 4169917..4170087 + 171 Protein_3984 IS110 family transposase -
QJP55_RS20330 (4170436) 4170436..4171935 + 1500 WP_000174401.1 IS21-like element ISEc10 family transposase -
QJP55_RS20335 (4171932) 4171932..4172687 + 756 Protein_3986 IS21-like element ISEc10 family helper ATPase IstB -
QJP55_RS20340 (4173313) 4173313..4174296 + 984 WP_001296394.1 KpsF/GutQ family sugar-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(34-292)

Antitoxin

Protein of unknown function DUF6088

(10-129)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 34298.40 Da        Isoelectric Point: 5.9850

>T280479 WP_001114681.1 NZ_CP124481:4168553-4169446 [Escherichia coli]
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN

Download         Length: 894 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14608.03 Da        Isoelectric Point: 11.3150

>AT280479 WP_000208383.1 NZ_CP124481:4168165-4168560 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3JHM4

Antitoxin

Source ID Structure
AlphaFold DB V0YCI1

References