Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4018767..4019421 Replicon chromosome
Accession NZ_CP124481
Organism Escherichia coli strain AVS0756

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QJP55_RS19515 Protein ID WP_000244765.1
Coordinates 4018767..4019174 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QJP55_RS19520 Protein ID WP_000354050.1
Coordinates 4019155..4019421 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP55_RS19495 (4014724) 4014724..4016457 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
QJP55_RS19500 (4016463) 4016463..4017173 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJP55_RS19505 (4017198) 4017198..4018094 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QJP55_RS19510 (4018206) 4018206..4018727 + 522 WP_001055874.1 flavodoxin FldB -
QJP55_RS19515 (4018767) 4018767..4019174 - 408 WP_000244765.1 protein YgfX Toxin
QJP55_RS19520 (4019155) 4019155..4019421 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QJP55_RS19525 (4019664) 4019664..4020644 + 981 WP_000886080.1 tRNA-modifying protein YgfZ -
QJP55_RS19530 (4020721) 4020721..4021380 - 660 WP_000250275.1 hemolysin III family protein -
QJP55_RS19535 (4021544) 4021544..4021855 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QJP55_RS19540 (4021900) 4021900..4023333 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T280477 WP_000244765.1 NZ_CP124481:c4019174-4018767 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT280477 WP_000354050.1 NZ_CP124481:c4019421-4019155 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References