280465

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2126319..2126790 Replicon chromosome
Accession NZ_CP124481
Organism Escherichia coli strain AVS0756

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QJP55_RS10220 Protein ID WP_001303511.1
Coordinates 2126319..2126597 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QJP55_RS10225 Protein ID WP_001302048.1
Coordinates 2126599..2126790 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP55_RS10185 (2121532) 2121532..2121801 - 270 WP_000003742.1 excisionase -
QJP55_RS10190 (2121863) 2121863..2124301 - 2439 WP_000102132.1 exonuclease -
QJP55_RS10195 (2124394) 2124394..2124582 - 189 WP_000199475.1 DUF1482 family protein -
QJP55_RS10200 (2124579) 2124579..2124767 - 189 WP_000449175.1 cell division inhibition protein DicB -
QJP55_RS10205 (2125343) 2125343..2125537 + 195 WP_001295058.1 hypothetical protein -
QJP55_RS10210 (2125526) 2125526..2125864 - 339 WP_000394541.1 hypothetical protein -
QJP55_RS10215 (2125876) 2125876..2126028 - 153 WP_000380313.1 DUF1391 family protein -
QJP55_RS10220 (2126319) 2126319..2126597 - 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJP55_RS10225 (2126599) 2126599..2126790 - 192 WP_001302048.1 hypothetical protein Antitoxin
QJP55_RS10230 (2126811) 2126811..2127182 - 372 WP_001169687.1 hypothetical protein -
QJP55_RS10235 (2127280) 2127280..2127582 + 303 WP_001556930.1 transcriptional regulator -
QJP55_RS10240 (2127579) 2127579..2128004 + 426 WP_000693943.1 toxin YdaT family protein -
QJP55_RS10245 (2128027) 2128027..2128989 + 963 WP_000095673.1 helix-turn-helix domain-containing protein -
QJP55_RS10250 (2128996) 2128996..2129742 + 747 WP_000788950.1 ATP-binding protein -
QJP55_RS10255 (2129764) 2129764..2130534 + 771 WP_000450998.1 DUF1627 domain-containing protein -
QJP55_RS10260 (2130550) 2130550..2130972 + 423 Protein_2004 DUF977 family protein -
QJP55_RS10265 (2131078) 2131078..2131290 + 213 WP_000072553.1 hypothetical protein -
QJP55_RS10270 (2131323) 2131323..2131541 + 219 WP_001610644.1 DUF4014 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2117922..2145175 27253
- inside Prophage sitABCD - 2113277..2312175 198898


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T280465 WP_001303511.1 NZ_CP124481:c2126597-2126319 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT280465 WP_001302048.1 NZ_CP124481:c2126790-2126599 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References