280463

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1458443..1459061 Replicon chromosome
Accession NZ_CP124481
Organism Escherichia coli strain AVS0756

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP55_RS07000 Protein ID WP_001291435.1
Coordinates 1458443..1458661 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP55_RS07005 Protein ID WP_000344800.1
Coordinates 1458687..1459061 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP55_RS06965 (1453731) 1453731..1454303 + 573 WP_000779841.1 YbaY family lipoprotein -
QJP55_RS06970 (1454334) 1454334..1454645 - 312 WP_000409908.1 MGMT family protein -
QJP55_RS06980 (1455024) 1455024..1455377 + 354 WP_000878147.1 DUF1428 family protein -
QJP55_RS06985 (1455419) 1455419..1456969 - 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP55_RS06990 (1457133) 1457133..1457603 - 471 WP_000136192.1 YlaC family protein -
QJP55_RS06995 (1457719) 1457719..1458270 - 552 WP_000102539.1 maltose O-acetyltransferase -
QJP55_RS07000 (1458443) 1458443..1458661 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP55_RS07005 (1458687) 1458687..1459061 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP55_RS07010 (1459607) 1459607..1462756 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP55_RS07015 (1462779) 1462779..1463972 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T280463 WP_001291435.1 NZ_CP124481:c1458661-1458443 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT280463 WP_000344800.1 NZ_CP124481:c1459061-1458687 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References