Detailed information of TA system TA280462

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1299674..1301363
• Replicon: chromosome
• Accession: NZ_CP124481
• Organism: Escherichia coli strain AVS0756

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP55_RS06235
• Protein ID: WP_000365807.1
• Coordinates: 1300443..1301363 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP55_RS06230
• Protein ID: WP_001295795.1
• Coordinates: 1299674..1300456 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP55_RS06225 (1296292)	1296292..1299390	-	3099	WP_000673070.1	type I restriction endonuclease	-
QJP55_RS06230 (1299674)	1299674..1300456	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP55_RS06235 (1300443)	1300443..1301363	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP55_RS06240 (1301528)	1301528..1302304	-	777	WP_000171155.1	site-specific integrase	-
QJP55_RS06245 (1302512)	1302512..1302847	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP55_RS06250 (1303074)	1303074..1303232	-	159	Protein_1220	integrase	-
QJP55_RS06255 (1303281)	1303281..1303466	+	186	WP_000146240.1	hypothetical protein	-
QJP55_RS06260 (1303681)	1303681..1304295	+	615	WP_001019923.1	YagU family protein	-
QJP55_RS06265 (1304366)	1304366..1304532	+	167	Protein_1223	tail fiber assembly protein	-
QJP55_RS06270 (1304544)	1304544..1304873	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP55_RS06275 (1305180)	1305180..1305890	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	1292611..1341576	48965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280462 WP_000365807.1 NZ_CP124481:1300443-1301363 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280462 WP_001295795.1 NZ_CP124481:1299674-1300456 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0