280461

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1069726..1070276 Replicon chromosome
Accession NZ_CP124481
Organism Escherichia coli strain AVS0756

Toxin (Protein)


Gene name ccdB Uniprot ID S1PDG4
Locus tag QJP55_RS05145 Protein ID WP_001160966.1
Coordinates 1069962..1070276 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag QJP55_RS05140 Protein ID WP_000125566.1
Coordinates 1069726..1069959 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP55_RS05115 (1064799) 1064799..1065086 + 288 WP_000203741.1 ferredoxin-like protein FixX -
QJP55_RS05120 (1065145) 1065145..1066476 + 1332 WP_001183207.1 MFS transporter -
QJP55_RS05125 (1066584) 1066584..1067114 + 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
QJP55_RS05130 (1067107) 1067107..1068969 + 1863 WP_000377124.1 glutathione-regulated potassium-efflux system protein KefC -
QJP55_RS05135 (1069161) 1069161..1069640 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
QJP55_RS05140 (1069726) 1069726..1069959 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QJP55_RS05145 (1069962) 1069962..1070276 + 315 WP_001160966.1 CcdB family protein Toxin
QJP55_RS05150 (1070273) 1070273..1071121 - 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
QJP55_RS05155 (1071128) 1071128..1071505 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
QJP55_RS05160 (1071508) 1071508..1072329 - 822 WP_001065363.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
QJP55_RS05165 (1072326) 1072326..1073315 - 990 WP_000241227.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
QJP55_RS05170 (1073315) 1073315..1074601 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.72 Da        Isoelectric Point: 9.0851

>T280461 WP_001160966.1 NZ_CP124481:1069962-1070276 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT280461 WP_000125566.1 NZ_CP124481:1069726-1069959 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G815

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References