280460

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 960225..960801 Replicon chromosome
Accession NZ_CP124481
Organism Escherichia coli strain AVS0756

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QJP55_RS04615 Protein ID WP_001297643.1
Coordinates 960225..960512 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QJP55_RS04620 Protein ID WP_000063156.1
Coordinates 960499..960801 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP55_RS04595 (956478) 956478..957758 - 1281 WP_001037382.1 DUF445 domain-containing protein -
QJP55_RS04600 (957799) 957799..959031 - 1233 WP_001339512.1 multidrug efflux MFS transporter MdtM -
QJP55_RS04605 (959177) 959177..959272 - 96 Protein_900 dienelactone hydrolase family protein -
QJP55_RS04610 (959329) 959329..960026 + 698 Protein_901 IS1 family transposase -
QJP55_RS04615 (960225) 960225..960512 + 288 WP_001297643.1 BrnT family toxin Toxin
QJP55_RS04620 (960499) 960499..960801 + 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QJP55_RS04625 (960835) 960835..961791 - 957 WP_001297640.1 GTPase -
QJP55_RS04630 (961802) 961802..962005 - 204 WP_000467859.1 YbdD/YjiX family protein -
QJP55_RS04635 (962055) 962055..964205 - 2151 WP_001295524.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T280460 WP_001297643.1 NZ_CP124481:960225-960512 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT280460 WP_000063156.1 NZ_CP124481:960499-960801 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References