Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 889111..889945 Replicon chromosome
Accession NZ_CP124481
Organism Escherichia coli strain AVS0756

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1J6XFW9
Locus tag QJP55_RS04245 Protein ID WP_000854770.1
Coordinates 889568..889945 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1N885
Locus tag QJP55_RS04240 Protein ID WP_001280950.1
Coordinates 889111..889479 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP55_RS04210 (884263) 884263..886164 + 1902 Protein_821 Ag43/Cah family autotransporter adhesin -
QJP55_RS04215 (886235) 886235..886430 + 196 Protein_822 DUF905 family protein -
QJP55_RS04220 (886548) 886548..887366 + 819 WP_001234712.1 DUF932 domain-containing protein -
QJP55_RS04225 (887708) 887708..888172 + 465 WP_000855061.1 antirestriction protein -
QJP55_RS04230 (888188) 888188..888664 + 477 WP_001186779.1 RadC family protein -
QJP55_RS04235 (888727) 888727..888948 + 222 WP_001220314.1 DUF987 domain-containing protein -
QJP55_RS04240 (889111) 889111..889479 + 369 WP_001280950.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QJP55_RS04245 (889568) 889568..889945 + 378 WP_000854770.1 TA system toxin CbtA family protein Toxin
QJP55_RS04250 (889942) 889942..890430 + 489 WP_000761690.1 DUF5983 family protein -
QJP55_RS04255 (890447) 890447..890623 + 177 WP_000839286.1 DUF957 domain-containing protein -
QJP55_RS04260 (890729) 890729..890878 + 150 Protein_831 hypothetical protein -
QJP55_RS04265 (891245) 891245..891550 + 306 Protein_832 helix-turn-helix domain-containing protein -
QJP55_RS04270 (892212) 892212..893834 + 1623 WP_001295726.1 Alw26I/Eco31I/Esp3I family type II restriction adenine-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 841273..901591 60318


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14196.37 Da        Isoelectric Point: 8.7438

>T280459 WP_000854770.1 NZ_CP124481:889568-889945 [Escherichia coli]
MKTLPDTHVRKVSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13737.56 Da        Isoelectric Point: 7.0268

>AT280459 WP_001280950.1 NZ_CP124481:889111-889479 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAFYPTSETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6XFW9

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1N885

References