Detailed information of TA system TA280440

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3912113..3913802
• Replicon: chromosome
• Accession: NZ_CP124475
• Organism: Escherichia coli strain AVS0969

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP78_RS19595
• Protein ID: WP_000365807.1
• Coordinates: 3912113..3913033 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP78_RS19600
• Protein ID: WP_001295795.1
• Coordinates: 3913020..3913802 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP78_RS19555 (3907586)	3907586..3908296	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJP78_RS19560 (3908603)	3908603..3908932	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP78_RS19565 (3908944)	3908944..3909110	-	167	Protein_3836	tail fiber assembly protein	-
QJP78_RS19570 (3909181)	3909181..3909795	-	615	WP_001019923.1	YagU family protein	-
QJP78_RS19575 (3910010)	3910010..3910195	-	186	WP_000146240.1	hypothetical protein	-
QJP78_RS19580 (3910244)	3910244..3910402	+	159	Protein_3839	integrase	-
QJP78_RS19585 (3910629)	3910629..3910964	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP78_RS19590 (3911172)	3911172..3911948	+	777	WP_000171155.1	site-specific integrase	-
QJP78_RS19595 (3912113)	3912113..3913033	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP78_RS19600 (3913020)	3913020..3913802	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP78_RS19605 (3914086)	3914086..3917184	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3871900..3920865	48965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280440 WP_000365807.1 NZ_CP124475:c3913033-3912113 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280440 WP_001295795.1 NZ_CP124475:c3913802-3913020 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0