Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 2751248..2752710 Replicon chromosome
Accession NC_018140
Organism Legionella pneumophila subsp. pneumophila

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag LPV_RS12235 Protein ID WP_014844517.1
Coordinates 2751248..2752105 (-) Length 286 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag LPV_RS12240 Protein ID WP_014844518.1
Coordinates 2752102..2752710 (-) Length 203 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPV_RS12220 2748073..2748645 + 573 WP_014844514.1 hypothetical protein -
LPV_RS12225 2748695..2750446 - 1752 WP_014844515.1 DUF927 domain-containing protein -
LPV_RS12230 2750530..2750805 - 276 WP_014844516.1 helix-turn-helix domain-containing protein -
LPV_RS12235 2751248..2752105 - 858 WP_014844517.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LPV_RS12240 2752102..2752710 - 609 WP_014844518.1 AbiEi antitoxin N-terminal domain-containing protein Antitoxin
LPV_RS12245 2752788..2752988 - 201 WP_027268450.1 hypothetical protein -
LPV_RS12250 2753106..2754338 - 1233 WP_027268449.1 integrase family protein -
LPV_RS12260 2754842..2756017 - 1176 WP_014844520.1 ISL3-like element ISLpn11 family transposase -
LPV_RS12265 2756098..2756862 - 765 Protein_2419 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2739455..2754560 15105
- flank IS/Tn - - 2754842..2756017 1175


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(37-261)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(7-93)


Sequences

Toxin        


Download         Length: 286 a.a.        Molecular weight: 31776.77 Da        Isoelectric Point: 6.2736

>T28044 WP_014844517.1 NC_018140:c2752105-2751248 [Legionella pneumophila subsp. pneumophila]
MTKDISASIRARLKKIAKAEGSKSDFIAVLTRYGLERLLYRIGISEYASQFLLKGALLFNLWYDMPHRPTKDIDLLGFGD
NDLAYIQKTFREICSLSADDGMNFLSKSVEVSTIKKDGGYTGARVELFGELAKAKIKIQVDIGYGDAVTPGPIDANYPVL
LSDLPAPQIRTYPVYTVIAEKLHAIALLGMANSRLKDYLDLYVLLTQEQLDNQVLAQAIHATFIRRGMTVPEVLPVGLSD
EFANDPTRISIWNAFLSKNELEQRSLTEVIEVIISLIQTPFSLAR

Download         Length: 858 bp

>T28044 NC_018140:c2752105-2751248 [Legionella pneumophila subsp. pneumophila]
ATGACAAAAGATATAAGTGCTTCCATTCGAGCACGACTTAAAAAAATAGCAAAAGCTGAAGGATCAAAGTCAGATTTTAT
TGCTGTCTTAACCCGTTATGGTCTCGAGCGACTGTTATACCGAATTGGCATATCTGAATACGCCAGTCAATTTTTACTAA
AAGGCGCTTTACTATTTAATCTTTGGTATGACATGCCGCACCGCCCAACCAAGGATATTGATTTATTAGGGTTTGGTGAT
AATGATCTGGCTTATATCCAGAAAACTTTCAGGGAAATTTGTAGTCTTTCAGCGGACGATGGGATGAATTTTCTTTCTAA
ATCTGTTGAAGTAAGCACTATCAAAAAAGATGGTGGTTATACTGGTGCAAGGGTTGAGTTATTTGGAGAGTTGGCAAAAG
CAAAGATCAAAATACAAGTTGATATTGGTTATGGAGATGCAGTAACTCCTGGCCCAATAGACGCTAATTACCCTGTACTT
TTAAGCGATCTTCCTGCTCCACAAATTCGTACTTATCCCGTTTATACTGTTATCGCAGAAAAATTGCACGCAATTGCATT
ATTGGGTATGGCTAATAGTCGATTGAAAGATTACTTAGACCTTTATGTGTTATTAACTCAAGAACAATTGGATAATCAAG
TTTTAGCCCAAGCTATACATGCCACATTTATTCGTCGGGGCATGACTGTACCTGAAGTACTACCTGTAGGTCTGTCCGAT
GAATTCGCCAATGACCCAACTAGAATATCAATTTGGAACGCTTTTTTAAGCAAAAATGAATTGGAACAGAGATCATTAAC
AGAAGTTATAGAGGTGATCATAAGTTTAATTCAAACACCATTTTCTTTGGCAAGGTAA

Antitoxin


Download         Length: 203 a.a.        Molecular weight: 22953.73 Da        Isoelectric Point: 9.2881

>AT28044 WP_014844518.1 NC_018140:c2752710-2752102 [Legionella pneumophila subsp. pneumophila]
MNTKNTHSQKALNLAKEKGIVRSSEFVEEGIPRIVISRLVANQQLQQIERGLYCLPEKEFSEKESLLVIATRVPQAIFCL
FTALQVHGLTTQLPRKIWIAMPIDSRVPKIDYPPIKMVKYSGEAYSQGIETQEADGVSFRVYNVAKTIADCFKHRNKIGM
DVAIEALKDAYAQNKVTADELWHYAKICRVAKVMRPYLEAIQ

Download         Length: 609 bp

>AT28044 NC_018140:c2752710-2752102 [Legionella pneumophila subsp. pneumophila]
ATGAATACTAAAAACACCCATAGTCAAAAGGCTCTGAATCTTGCTAAAGAAAAAGGAATCGTACGTTCCTCTGAGTTTGT
AGAAGAAGGCATTCCAAGAATCGTCATATCTCGTCTAGTTGCAAATCAACAATTGCAACAGATTGAGAGGGGGCTTTATT
GTCTTCCTGAAAAGGAATTCTCTGAAAAGGAGAGTTTGTTGGTTATTGCCACTCGAGTGCCACAAGCCATTTTTTGTCTT
TTTACAGCACTTCAAGTTCATGGACTTACTACACAATTGCCAAGAAAGATTTGGATAGCCATGCCTATTGATAGTCGTGT
ACCTAAAATAGATTATCCACCTATAAAAATGGTGAAGTATTCAGGAGAAGCTTATTCTCAGGGGATTGAAACGCAAGAGG
CTGATGGTGTTTCATTTCGTGTATATAATGTTGCTAAAACAATTGCTGATTGCTTTAAGCATAGGAATAAAATTGGTATG
GATGTAGCAATTGAAGCTTTGAAAGATGCCTATGCCCAAAATAAAGTGACTGCTGATGAACTATGGCATTATGCGAAAAT
TTGTCGTGTTGCAAAAGTAATGCGTCCTTATCTAGAGGCTATCCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References