Detailed information of TA system TA028043

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prpT-prpA/CC2985(antitoxin)
• Location: 2425078..2425618
• Replicon: chromosome
• Accession: NC_018140
• Organism: Legionella pneumophila subsp. pneumophila

Toxin (Protein)

• Gene name: PrpT
• Uniprot ID: -
• Locus tag: LPV_RS10895
• Protein ID: WP_014844324.1
• Coordinates: 2425322..2425618 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PrpA
• Uniprot ID: A0A0W1AP56
• Locus tag: LPV_RS10890
• Protein ID: WP_014844323.1
• Coordinates: 2425078..2425332 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPV_RS10860	2420809..2422107	+	1299	WP_014844320.1	hydroxymethylglutaryl-CoA reductase, degradative	-
LPV_RS10865	2422104..2422982	+	879	WP_014844321.1	hypothetical protein	-
LPV_RS10885	2423481..2424764	+	1284	WP_014844322.1	hypothetical protein	-
LPV_RS10890	2425078..2425332	+	255	WP_014844323.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
LPV_RS10895	2425322..2425618	+	297	WP_014844324.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LPV_RS10905	2426079..2426819	-	741	Protein_2157	transposase family protein	-
LPV_RS10910	2426885..2427679	-	795	WP_014844325.1	IS21-like element ISLpn12 family helper ATPase IstB	-
LPV_RS10915	2427676..2428698	-	1023	WP_077383491.1	IS21-like element ISLpn12 family transposase	-
LPV_RS10920	2428816..2429095	-	280	Protein_2160	helix-turn-helix domain containing protein	-
LPV_RS10925	2429358..2429567	+	210	WP_010947832.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-94)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11582.28 Da
• Isoelectric Point: 7.2728

>T28043 WP_014844324.1 NC_018140:2425322-2425618 [Legionella pneumophila subsp. pneumophila]
MSNKTYRLYPKAVEDLESIYLYSTNEFGIKRTEDYILAIDLSFQRLADDPLIARKCDYIRPELRAFNVGSHIIFFKTTDY
GISVIRVLHQSMDFNRHL

Nucleotide

• Length: 297 bp

>T28043 NC_018140:2425322-2425618 [Legionella pneumophila subsp. pneumophila]
ATGTCAAATAAAACATATCGTCTTTACCCAAAAGCGGTAGAAGATCTTGAGTCCATCTATTTATATAGCACAAATGAGTT
TGGTATCAAACGAACAGAGGATTATATTTTAGCTATAGATTTAAGTTTTCAGCGCCTTGCAGATGATCCCTTAATTGCTC
GAAAATGTGATTATATTCGTCCAGAATTACGCGCATTTAATGTTGGCTCTCACATTATTTTTTTCAAAACTACCGATTAC
GGCATTTCTGTTATTCGAGTGTTGCATCAATCTATGGATTTTAATAGACATCTATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9844.18 Da
• Isoelectric Point: 9.5928

>AT28043 WP_014844323.1 NC_018140:2425078-2425332 [Legionella pneumophila subsp. pneumophila]
MTRTMTVDLGNELRNYVESLVRSGDYRSNSEVLRESLRLLREKQAESKLEQLRHLIDEGEASGKPETWDAHDFLKKMKKK
SHVK

Nucleotide

• Length: 255 bp

>AT28043 NC_018140:2425078-2425332 [Legionella pneumophila subsp. pneumophila]
ATGACCCGTACAATGACTGTTGATTTGGGTAATGAACTTCGTAATTACGTGGAATCACTTGTACGCTCAGGGGATTATAG
AAGTAATAGCGAAGTATTAAGAGAGTCGTTGCGTTTACTTCGTGAAAAACAAGCTGAATCAAAACTAGAGCAGTTGCGTC
ACCTTATAGATGAAGGGGAAGCTAGCGGGAAGCCTGAAACATGGGATGCACATGATTTTCTTAAGAAAATGAAGAAAAAA
TCCCATGTCAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0W1AP56