Detailed information of TA system TA028042

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3365947..3366484
• Replicon: chromosome
• Accession: NC_018139
• Organism: Legionella pneumophila subsp. pneumophila

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LPO_RS15155
• Protein ID: WP_014842909.1
• Coordinates: 3365947..3366243 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LPO_RS15160
• Protein ID: WP_014842910.1
• Coordinates: 3366233..3366484 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPO_RS15135	3362155..3363048	-	894	WP_014842905.1	hypothetical protein	-
LPO_RS15140	3363316..3363507	+	192	WP_014842906.1	hypothetical protein	-
LPO_RS17335	3363656..3363769	-	114	Protein_2958	lytic murein transglycosylase	-
LPO_RS16530	3363854..3365017	-	1164	WP_014842907.1	sel1 repeat family protein	-
LPO_RS15150	3365376..3365858	-	483	WP_014842908.1	hypothetical protein	-
LPO_RS15155	3365947..3366243	-	297	WP_014842909.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LPO_RS15160	3366233..3366484	-	252	WP_014842910.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LPO_RS15170	3367065..3367568	-	504	WP_014842912.1	hypothetical protein	-
LPO_RS15175	3367677..3368723	-	1047	WP_014842913.1	FAD-dependent oxidoreductase	-
LPO_RS15180	3369030..3369992	-	963	WP_014842914.1	lytic murein transglycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-60)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11482.33 Da
• Isoelectric Point: 10.3916

>T28042 WP_014842909.1 NC_018139:c3366243-3365947 [Legionella pneumophila subsp. pneumophila]
MIYELHFHPLALKEWKKLGKNLQEEFKKVLKRRLENPHVASAGLRGSLKNCYKIKLRQSGYRLVYQVNDNKLIVTVIAVG
KRNKNVVYDDADNRQEDS

Nucleotide

• Length: 297 bp

>T28042 NC_018139:c3366243-3365947 [Legionella pneumophila subsp. pneumophila]
ATGATTTATGAGCTTCATTTTCATCCTTTAGCTTTAAAAGAATGGAAAAAGCTGGGGAAAAACCTTCAAGAAGAATTTAA
GAAAGTGTTAAAACGCCGTTTAGAAAATCCACATGTGGCTTCGGCTGGCTTAAGAGGCTCTTTAAAAAATTGCTATAAAA
TAAAATTACGTCAATCTGGTTATCGTTTGGTGTATCAAGTTAATGATAATAAATTAATTGTAACCGTCATAGCAGTCGGG
AAAAGAAACAAAAATGTTGTCTATGATGATGCAGATAACCGACAAGAAGACAGTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9285.72 Da
• Isoelectric Point: 5.0359

>AT28042 WP_014842910.1 NC_018139:c3366484-3366233 [Legionella pneumophila subsp. pneumophila]
MQTLFATQVASISELKKNPTKLINDAHGKPIAILNHNTAAAYLIPVETFEKLMDLIDENELHKIVEERLSAPFTSIKVNI
DDL

Nucleotide

• Length: 252 bp

>AT28042 NC_018139:c3366484-3366233 [Legionella pneumophila subsp. pneumophila]
ATGCAAACTTTATTTGCTACACAAGTAGCGAGCATTAGTGAATTAAAAAAGAACCCCACTAAGCTCATTAATGATGCTCA
TGGAAAACCTATTGCTATTCTTAACCACAATACAGCGGCAGCATATTTAATTCCTGTTGAAACATTTGAAAAACTAATGG
ATTTGATTGATGAGAATGAACTACATAAAATAGTAGAAGAGCGTTTGTCAGCACCTTTTACCTCAATAAAGGTAAATATT
GATGATTTATGA