Detailed information of TA system TA280415

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3806482..3808171
• Replicon: chromosome
• Accession: NZ_CP124471
• Organism: Escherichia coli strain AVS0973

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP95_RS18720
• Protein ID: WP_000365807.1
• Coordinates: 3806482..3807402 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP95_RS18725
• Protein ID: WP_001295795.1
• Coordinates: 3807389..3808171 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP95_RS18680 (3801955)	3801955..3802665	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJP95_RS18685 (3802972)	3802972..3803301	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP95_RS18690 (3803313)	3803313..3803479	-	167	Protein_3669	tail fiber assembly protein	-
QJP95_RS18695 (3803550)	3803550..3804164	-	615	WP_001019923.1	YagU family protein	-
QJP95_RS18700 (3804379)	3804379..3804564	-	186	WP_000146240.1	hypothetical protein	-
QJP95_RS18705 (3804613)	3804613..3804771	+	159	Protein_3672	integrase	-
QJP95_RS18710 (3804998)	3804998..3805333	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP95_RS18715 (3805541)	3805541..3806317	+	777	WP_000171155.1	site-specific integrase	-
QJP95_RS18720 (3806482)	3806482..3807402	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP95_RS18725 (3807389)	3807389..3808171	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP95_RS18730 (3808455)	3808455..3811553	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3766269..3815234	48965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280415 WP_000365807.1 NZ_CP124471:c3807402-3806482 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280415 WP_001295795.1 NZ_CP124471:c3808171-3807389 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0