Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3623193..3623811 Replicon chromosome
Accession NZ_CP124471
Organism Escherichia coli strain AVS0973

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP95_RS17860 Protein ID WP_001291435.1
Coordinates 3623593..3623811 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP95_RS17855 Protein ID WP_000344800.1
Coordinates 3623193..3623567 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP95_RS17845 (3618282) 3618282..3619475 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QJP95_RS17850 (3619498) 3619498..3622647 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP95_RS17855 (3623193) 3623193..3623567 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP95_RS17860 (3623593) 3623593..3623811 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP95_RS17865 (3623984) 3623984..3624535 + 552 WP_000102539.1 maltose O-acetyltransferase -
QJP95_RS17870 (3624651) 3624651..3625121 + 471 WP_000136192.1 YlaC family protein -
QJP95_RS17875 (3625285) 3625285..3626835 + 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP95_RS17880 (3626877) 3626877..3627230 - 354 WP_000878147.1 DUF1428 family protein -
QJP95_RS17890 (3627609) 3627609..3627920 + 312 WP_000409908.1 MGMT family protein -
QJP95_RS17895 (3627951) 3627951..3628523 - 573 WP_000779841.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T280414 WP_001291435.1 NZ_CP124471:3623593-3623811 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT280414 WP_000344800.1 NZ_CP124471:3623193-3623567 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References