Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 970232..970886 Replicon chromosome
Accession NZ_CP124471
Organism Escherichia coli strain AVS0973

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QJP95_RS04770 Protein ID WP_000244765.1
Coordinates 970479..970886 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QJP95_RS04765 Protein ID WP_000354050.1
Coordinates 970232..970498 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP95_RS04745 (966320) 966320..967753 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
QJP95_RS04750 (967798) 967798..968109 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QJP95_RS04755 (968273) 968273..968932 + 660 WP_000250275.1 hemolysin III family protein -
QJP95_RS04760 (969009) 969009..969989 - 981 WP_000886080.1 tRNA-modifying protein YgfZ -
QJP95_RS04765 (970232) 970232..970498 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QJP95_RS04770 (970479) 970479..970886 + 408 WP_000244765.1 protein YgfX Toxin
QJP95_RS04775 (970926) 970926..971447 - 522 WP_001055874.1 flavodoxin FldB -
QJP95_RS04780 (971559) 971559..972455 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QJP95_RS04785 (972480) 972480..973190 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJP95_RS04790 (973196) 973196..974929 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T280405 WP_000244765.1 NZ_CP124471:970479-970886 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT280405 WP_000354050.1 NZ_CP124471:970232-970498 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References