Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1121856..1123290 Replicon chromosome
Accession NC_018139
Organism Legionella pneumophila subsp. pneumophila

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag LPO_RS05080 Protein ID WP_115245468.1
Coordinates 1121856..1123061 (-) Length 402 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag LPO_RS05085 Protein ID WP_041174119.1
Coordinates 1123063..1123290 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPO_RS05060 1116856..1118661 + 1806 WP_014841325.1 GNAT family N-acetyltransferase -
LPO_RS05065 1118774..1119379 + 606 WP_014841326.1 class I SAM-dependent methyltransferase -
LPO_RS05070 1119419..1119913 + 495 WP_014841327.1 GNAT family N-acetyltransferase -
LPO_RS05075 1120210..1121478 - 1269 WP_041174042.1 lpg2372 family Dot/Icm T4SS effector -
LPO_RS05080 1121856..1123061 - 1206 WP_115245468.1 type II toxin-antitoxin system HipA family toxin Toxin
LPO_RS05085 1123063..1123290 - 228 WP_041174119.1 helix-turn-helix transcriptional regulator Antitoxin
LPO_RS05090 1123765..1124220 + 456 WP_014841331.1 GNAT family N-acetyltransferase -
LPO_RS05095 1124777..1125445 + 669 WP_011213452.1 HAD family phosphatase -
LPO_RS05100 1125599..1125805 + 207 WP_014841332.1 hypothetical protein -
LPO_RS05105 1125943..1126401 + 459 WP_011946203.1 hypothetical protein -
LPO_RS05110 1126524..1127126 + 603 WP_014841333.1 exopolysaccharide biosynthesis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(2-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-61)


Sequences

Toxin        


Download         Length: 402 a.a.        Molecular weight: 44692.92 Da        Isoelectric Point: 7.4399

>T28040 WP_115245468.1 NC_018139:c1123061-1121856 [Legionella pneumophila subsp. pneumophila]
MDVYLNQMLAGQLSIDTHGDMSFVYNDGYLENKKNLPLSHSLPLQQAPYSTKQCRPFFSGLLPEAHMRTAIARQLGISEK
NDFALLAAIGGECAGAVMILPQNTSIVQLKPDYKIIKKKDVLDILQTMHQRPMIVGEDGIRLSLAGAQDKLPVAIIEGNL
AIPMNGAPSTHILKPINRDFPTLIENECFCLNLAQKIGLNAVDAAIHYADDTPYLLVKRYDRVETEQGIKHLHQEDFCQA
MGIGPEMKYQREGGPQISECFGLIREISSLPVFDIKELLQGILFNVIIGNNDAHSKNFSLLYHGSKARLAPFYDMISTVY
YPNLAGKMAMKVGCKYDFDSLFPRHFIQMAEEARLSGALVCKEVLSLISKIQKNITASPFTSIILQRADKLFQRFQKISA
G

Download         Length: 1206 bp

>T28040 NC_018139:c1123061-1121856 [Legionella pneumophila subsp. pneumophila]
CTGGATGTCTATCTTAACCAAATGCTAGCAGGCCAATTAAGTATTGATACGCATGGCGACATGTCTTTTGTGTATAATGA
CGGCTACCTGGAAAACAAGAAAAATCTCCCGTTATCACACTCCCTTCCTCTTCAACAAGCGCCTTACTCAACTAAGCAAT
GCCGTCCGTTTTTTAGCGGACTATTGCCTGAAGCCCATATGCGTACTGCTATTGCTCGTCAATTGGGTATCAGTGAAAAA
AACGATTTTGCCTTATTAGCTGCTATTGGTGGTGAGTGTGCCGGGGCTGTGATGATATTGCCTCAAAATACATCTATAGT
TCAGCTAAAGCCAGACTATAAAATTATCAAAAAAAAGGACGTATTAGACATCCTGCAAACCATGCATCAAAGGCCTATGA
TAGTTGGTGAAGATGGAATCCGCCTATCCCTTGCAGGCGCTCAGGATAAGCTCCCAGTTGCTATTATTGAAGGAAATCTC
GCAATACCAATGAACGGTGCACCCAGTACTCACATTTTAAAACCAATCAATCGAGACTTTCCCACCCTAATTGAAAATGA
GTGTTTCTGCCTTAACCTGGCACAAAAAATTGGATTAAATGCTGTGGACGCAGCTATCCATTACGCTGATGATACTCCTT
ATCTGTTGGTTAAACGTTATGATCGGGTTGAGACAGAGCAAGGAATCAAACACCTTCATCAAGAAGATTTTTGTCAGGCA
ATGGGCATTGGCCCTGAAATGAAATATCAGCGAGAAGGCGGCCCCCAAATTAGTGAGTGCTTTGGTTTGATAAGAGAGAT
ATCAAGTCTCCCTGTCTTTGACATAAAAGAATTATTACAAGGGATTCTGTTTAATGTCATTATTGGCAACAATGATGCAC
ACAGCAAAAACTTCTCTTTGCTCTATCATGGTTCAAAAGCTCGTTTAGCACCTTTCTACGATATGATTTCAACCGTATAT
TATCCTAATCTTGCCGGTAAAATGGCGATGAAAGTTGGATGTAAATATGATTTTGATAGCCTATTTCCACGCCACTTTAT
ACAAATGGCAGAGGAAGCTCGTTTATCGGGTGCCCTAGTGTGTAAAGAAGTCTTGAGTCTAATTAGCAAAATTCAAAAGA
ACATTACGGCTAGCCCCTTTACCAGCATCATTTTGCAACGTGCTGACAAATTATTTCAAAGGTTTCAGAAGATTTCAGCA
GGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8368.66 Da        Isoelectric Point: 8.0148

>AT28040 WP_041174119.1 NC_018139:c1123290-1123063 [Legionella pneumophila subsp. pneumophila]
MIQSPENIGSYIRKVRKELNVTQKDLALTAGTGLRFIIDLENGKPTCQIGKTLQVLQVLGIQLNLSHTDFENEKS

Download         Length: 228 bp

>AT28040 NC_018139:c1123290-1123063 [Legionella pneumophila subsp. pneumophila]
ATGATTCAATCTCCAGAAAATATAGGAAGTTATATTCGCAAAGTTCGTAAAGAGCTTAATGTTACCCAAAAAGATTTGGC
TTTAACTGCTGGAACTGGATTGCGTTTTATTATTGATTTGGAAAATGGAAAGCCCACTTGCCAAATTGGAAAAACACTGC
AAGTACTGCAAGTACTTGGGATTCAACTTAACTTATCTCATACTGATTTCGAAAATGAAAAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References