Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataT-KacA/DUF1778(antitoxin)
Location 30654..31452 Replicon plasmid pAVS0747-B
Accession NZ_CP124469
Organism Escherichia coli strain AVS0747

Toxin (Protein)


Gene name ataT Uniprot ID E2QDF3
Locus tag QJB08_RS24595 Protein ID WP_000072677.1
Coordinates 30931..31452 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A0V9R6Q7
Locus tag QJB08_RS24590 Protein ID WP_001351987.1
Coordinates 30654..30923 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB08_RS24565 (QJB08_24565) 26080..27420 - 1341 WP_000137333.1 DnaB-like helicase C-terminal domain-containing protein -
QJB08_RS24570 (QJB08_24570) 27465..28205 - 741 WP_001717320.1 hypothetical protein -
QJB08_RS24575 (QJB08_24575) 28488..29255 + 768 WP_021547968.1 hypothetical protein -
QJB08_RS24580 (QJB08_24580) 29308..29661 - 354 WP_160394000.1 hypothetical protein -
QJB08_RS24585 (QJB08_24585) 29667..30335 - 669 WP_053902532.1 division plane positioning ATPase MipZ -
QJB08_RS24590 (QJB08_24590) 30654..30923 + 270 WP_001351987.1 DUF1778 domain-containing protein Antitoxin
QJB08_RS24595 (QJB08_24595) 30931..31452 + 522 WP_000072677.1 GNAT family N-acetyltransferase Toxin
QJB08_RS24600 (QJB08_24600) 31621..31872 - 252 WP_257188412.1 hypothetical protein -
QJB08_RS24605 (QJB08_24605) 31874..32566 - 693 WP_000856757.1 hypothetical protein -
QJB08_RS24610 (QJB08_24610) 32580..32903 - 324 WP_000064175.1 hypothetical protein -
QJB08_RS24615 (QJB08_24615) 33085..33369 - 285 WP_283187881.1 hypothetical protein -
QJB08_RS24620 (QJB08_24620) 33412..34452 - 1041 WP_283187882.1 tail fiber domain-containing protein -
QJB08_RS24625 (QJB08_24625) 34462..34743 - 282 WP_021518236.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..105196 105196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19392.17 Da        Isoelectric Point: 8.6369

>T280399 WP_000072677.1 NZ_CP124469:30931-31452 [Escherichia coli]
VSNTTIEIFSGEKDYDLNGFDCGEESLNAFLANHLKRQHEGKILRAYVLCTQEERPKVLGYYTLSGSCFEKESLPSRSKQ
KKVPYRNVPSVTLGRLALDKSLQGQGFGSMLVTHAMRVVYNASLAVGIHGLFVEALNDKAKAFYKSLGFIQLVGNNERSL
FYPTKSIEKLFEE

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10082.54 Da        Isoelectric Point: 7.0155

>AT280399 WP_001351987.1 NZ_CP124469:30654-30923 [Escherichia coli]
MSALKKQRIDLRLTDDDKSIIEEAAAMSNQSITQFMVSSASERAVKVIEQHRRLVLNEESWNLVMDAISNPPAPNDKLKR
AADRLKSME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9R6P3

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9R6Q7

References