Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 14027..14574 Replicon plasmid pAVS0747-A
Accession NZ_CP124468
Organism Escherichia coli strain AVS0747

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QJB08_RS23875 Protein ID WP_244442846.1
Coordinates 14296..14574 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag QJB08_RS23870 Protein ID WP_000079941.1
Coordinates 14027..14296 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB08_RS23845 (9701) 9701..10456 + 756 Protein_11 IS110-like element IS5075 family transposase -
QJB08_RS23850 (10728) 10728..10814 - 87 Protein_12 Arm DNA-binding domain-containing protein -
QJB08_RS23855 (11144) 11144..11959 + 816 WP_001043260.1 sulfonamide-resistant dihydropteroate synthase Sul2 -
QJB08_RS23860 (12046) 12046..12288 + 243 Protein_14 phosphoglucosamine mutase -
QJB08_RS23865 (12524) 12524..13669 - 1146 Protein_15 IS91-like element ISVsa3 family transposase -
QJB08_RS23870 (14027) 14027..14296 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QJB08_RS23875 (14296) 14296..14574 + 279 WP_244442846.1 type II toxin-antitoxin system toxin YacB Toxin
QJB08_RS23880 (14614) 14614..15462 + 849 WP_021265674.1 3'-5' exonuclease -
QJB08_RS23885 (15579) 15579..16052 + 474 WP_001334658.1 hypothetical protein -
QJB08_RS23890 (16529) 16529..16795 - 267 WP_000955263.1 hypothetical protein -
QJB08_RS23895 (16795) 16795..17289 - 495 WP_001459505.1 hypothetical protein -
QJB08_RS23900 (17345) 17345..17947 - 603 WP_000517695.1 ProQ/FINO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / sul2 / blaCTX-M-1 - 1..109429 109429


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10761.43 Da        Isoelectric Point: 9.7617

>T280398 WP_244442846.1 NZ_CP124468:14296-14574 [Escherichia coli]
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT280398 WP_000079941.1 NZ_CP124468:14027-14296 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References