Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3489029..3489647 Replicon chromosome
Accession NZ_CP124467
Organism Escherichia coli strain AVS0747

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJB08_RS17020 Protein ID WP_001291435.1
Coordinates 3489429..3489647 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJB08_RS17015 Protein ID WP_000344800.1
Coordinates 3489029..3489403 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB08_RS17005 (3484118) 3484118..3485311 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QJB08_RS17010 (3485334) 3485334..3488483 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJB08_RS17015 (3489029) 3489029..3489403 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJB08_RS17020 (3489429) 3489429..3489647 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QJB08_RS17025 (3489821) 3489821..3490372 + 552 WP_000102539.1 maltose O-acetyltransferase -
QJB08_RS17030 (3490488) 3490488..3490958 + 471 WP_000136192.1 YlaC family protein -
QJB08_RS17035 (3491122) 3491122..3492672 + 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJB08_RS17040 (3492714) 3492714..3493067 - 354 WP_000878135.1 DUF1428 family protein -
QJB08_RS17050 (3493446) 3493446..3493757 + 312 WP_000409908.1 MGMT family protein -
QJB08_RS17055 (3493788) 3493788..3494360 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T280393 WP_001291435.1 NZ_CP124467:3489429-3489647 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT280393 WP_000344800.1 NZ_CP124467:3489029-3489403 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References