Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2420855..2422443 Replicon chromosome
Accession NZ_CP124467
Organism Escherichia coli strain AVS0747

Toxin (Protein)


Gene name hipA Uniprot ID A0A061YM43
Locus tag QJB08_RS11800 Protein ID WP_001125411.1
Coordinates 2421121..2422443 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A061YNW4
Locus tag QJB08_RS11795 Protein ID WP_001296076.1
Coordinates 2420855..2421121 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB08_RS11780 (2417223) 2417223..2418674 + 1452 WP_218287487.1 tagaturonate reductase -
QJB08_RS11785 (2418871) 2418871..2419785 + 915 WP_001296077.1 bestrophin family protein -
QJB08_RS11790 (2419789) 2419789..2420547 - 759 WP_001286537.1 trans-aconitate 2-methyltransferase -
QJB08_RS11795 (2420855) 2420855..2421121 + 267 WP_001296076.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QJB08_RS11800 (2421121) 2421121..2422443 + 1323 WP_001125411.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QJB08_RS11805 (2423354) 2423354..2423917 + 564 WP_001296074.1 type 1 fimbrial major subunit FimA -
QJB08_RS11810 (2424279) 2424279..2424551 + 273 Protein_2318 fimbria/pilus periplasmic chaperone -
QJB08_RS11815 (2424551) 2424551..2425288 + 738 Protein_2319 fimbria/pilus outer membrane usher protein -
QJB08_RS11820 (2425302) 2425302..2425832 + 531 WP_000876789.1 fimbrial protein -
QJB08_RS11825 (2425845) 2425845..2426348 + 504 WP_000825466.1 fimbrial protein -
QJB08_RS11830 (2426408) 2426408..2427322 + 915 WP_000520593.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49329.96 Da        Isoelectric Point: 7.7906

>T280391 WP_001125411.1 NZ_CP124467:2421121-2422443 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAAEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHDRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9987.34 Da        Isoelectric Point: 4.9632

>AT280391 WP_001296076.1 NZ_CP124467:2420855-2421121 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061YM43

Antitoxin

Source ID Structure
AlphaFold DB A0A061YNW4

References