Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 913117..913771 Replicon chromosome
Accession NZ_CP124467
Organism Escherichia coli strain AVS0747

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QJB08_RS04500 Protein ID WP_000244765.1
Coordinates 913364..913771 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QJB08_RS04495 Protein ID WP_000354050.1
Coordinates 913117..913383 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB08_RS04475 (909205) 909205..910638 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
QJB08_RS04480 (910683) 910683..910994 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QJB08_RS04485 (911158) 911158..911817 + 660 WP_218287456.1 hemolysin III family protein -
QJB08_RS04490 (911894) 911894..912874 - 981 WP_000886080.1 tRNA-modifying protein YgfZ -
QJB08_RS04495 (913117) 913117..913383 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QJB08_RS04500 (913364) 913364..913771 + 408 WP_000244765.1 protein YgfX Toxin
QJB08_RS04505 (913811) 913811..914332 - 522 WP_001055874.1 flavodoxin FldB -
QJB08_RS04510 (914444) 914444..915340 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QJB08_RS04515 (915365) 915365..916075 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJB08_RS04520 (916081) 916081..917814 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T280384 WP_000244765.1 NZ_CP124467:913364-913771 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT280384 WP_000354050.1 NZ_CP124467:913117-913383 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References