Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 289031..289831 Replicon chromosome
Accession NZ_CP124467
Organism Escherichia coli strain AVS0747

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJB08_RS01345 Protein ID WP_000342452.1
Coordinates 289304..289831 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJB08_RS01340 Protein ID WP_001277107.1
Coordinates 289031..289297 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB08_RS01320 (284690) 284690..285358 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
QJB08_RS01325 (285351) 285351..286409 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
QJB08_RS01330 (286654) 286654..287508 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJB08_RS01335 (287779) 287779..288882 + 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJB08_RS01340 (289031) 289031..289297 + 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJB08_RS01345 (289304) 289304..289831 + 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJB08_RS01350 (289828) 289828..290211 - 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJB08_RS01355 (290634) 290634..291743 + 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJB08_RS01360 (291791) 291791..292717 + 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJB08_RS01365 (292714) 292714..293991 + 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJB08_RS01370 (293988) 293988..294755 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T280381 WP_000342452.1 NZ_CP124467:289304-289831 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT280381 WP_001277107.1 NZ_CP124467:289031-289297 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References