Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 7797..8369 Replicon plasmid pAVS0947-C
Accession NZ_CP124463
Organism Escherichia coli strain AVS0947

Toxin (Protein)


Gene name VapD Uniprot ID -
Locus tag QJP79_RS25670 Protein ID WP_000270923.1
Coordinates 7797..8075 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID -
Locus tag QJP79_RS25675 Protein ID WP_001259444.1
Coordinates 8079..8369 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP79_RS25630 (QJP79_25630) 3089..3396 + 308 Protein_4 CcgAII protein -
QJP79_RS25635 (QJP79_25635) 3462..3854 + 393 WP_283201929.1 hypothetical protein -
QJP79_RS25640 (QJP79_25640) 4321..4806 + 486 WP_001061740.1 hypothetical protein -
QJP79_RS25645 (QJP79_25645) 5329..5604 + 276 WP_000085132.1 hypothetical protein -
QJP79_RS25650 (QJP79_25650) 5852..5986 + 135 WP_283201930.1 hypothetical protein -
QJP79_RS25655 (QJP79_25655) 6305..6926 + 622 Protein_9 AAA family ATPase -
QJP79_RS25660 (QJP79_25660) 6923..7132 + 210 WP_000041404.1 plasmid partition protein ParG -
QJP79_RS25665 (QJP79_25665) 7161..7712 + 552 WP_283201931.1 YjeJ family protein -
QJP79_RS25670 (QJP79_25670) 7797..8075 - 279 WP_000270923.1 virulence factor Toxin
QJP79_RS25675 (QJP79_25675) 8079..8369 - 291 WP_001259444.1 DUF5397 family protein Antitoxin
QJP79_RS25680 (QJP79_25680) 8388..8687 - 300 WP_001370935.1 helix-turn-helix transcriptional regulator -
QJP79_RS25685 (QJP79_25685) 9059..9543 + 485 Protein_15 hypothetical protein -
QJP79_RS25690 (QJP79_25690) 9746..10096 + 351 WP_021526599.1 hypothetical protein -
QJP79_RS25695 (QJP79_25695) 10664..11260 - 597 WP_021528077.1 hypothetical protein -
QJP79_RS25700 (QJP79_25700) 11519..11716 - 198 WP_283201932.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..35356 35356


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(38-96)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10571.82 Da        Isoelectric Point: 6.4606

>T280380 WP_000270923.1 NZ_CP124463:c8075-7797 [Escherichia coli]
MYAISFDLTVADTEKHHPKGVSQAYNDISSTLKRYGFERIQGSLYTNSDENMANLFQAMNALKALEWFPNSVRDIRAFRI
EQWSDFTSSIKG

Download         Length: 279 bp

>T280380 NZ_CP124463:c8075-7797 [Escherichia coli]
ATGTACGCAATATCATTTGATTTAACCGTTGCAGATACAGAAAAACATCATCCGAAAGGCGTGTCACAGGCTTACAACGA
TATAAGTTCGACCCTTAAAAGGTACGGATTTGAGCGAATCCAGGGAAGCCTGTACACAAATAGCGATGAAAATATGGCAA
ACCTTTTTCAGGCTATGAACGCATTAAAAGCTCTTGAATGGTTCCCAAATTCAGTCAGGGATATCAGAGCATTCAGGATT
GAACAGTGGTCTGACTTCACTTCGTCTATAAAGGGTTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10509.23 Da        Isoelectric Point: 4.2346

>AT280380 WP_001259444.1 NZ_CP124463:c8369-8079 [Escherichia coli]
MRTLEEVIAAQSPESQAIIKAMADKMRLEIGVKTMNTVQIPTGTIKTFGLLGIPYEVGEPAQELPDGDILVNIILVQTGE
KELYKLSKLLQDPDAE

Download         Length: 291 bp

>AT280380 NZ_CP124463:c8369-8079 [Escherichia coli]
ATGAGAACATTAGAAGAAGTAATTGCGGCCCAGTCACCTGAAAGTCAGGCTATTATCAAAGCTATGGCTGATAAGATGAG
GCTGGAAATCGGAGTGAAAACAATGAATACAGTGCAGATTCCAACAGGTACGATTAAGACATTCGGGCTGCTTGGTATTC
CTTACGAGGTAGGAGAGCCAGCCCAGGAACTACCCGATGGTGATATTCTTGTCAACATTATACTGGTTCAGACAGGTGAG
AAAGAGTTGTACAAACTTTCAAAACTATTACAAGATCCTGATGCAGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References