Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 67614..69151 Replicon chromosome
Accession NC_018139
Organism Legionella pneumophila subsp. pneumophila

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LPO_RS00335 Protein ID WP_032832233.1
Coordinates 67614..68918 (-) Length 435 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LPO_RS00340 Protein ID WP_014840730.1
Coordinates 68912..69151 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPO_RS00310 63171..64418 + 1248 WP_014840725.1 SdbB protein (substrate of the Dot/Icm system) -
LPO_RS00315 64715..65119 - 405 WP_014840726.1 MerR family transcriptional regulator -
LPO_RS00320 65189..65932 + 744 WP_014840727.1 glutaredoxin family protein -
LPO_RS00325 66132..67223 + 1092 WP_027220325.1 hypothetical protein -
LPO_RS00330 67265..67583 + 319 Protein_62 integrase -
LPO_RS00335 67614..68918 - 1305 WP_032832233.1 type II toxin-antitoxin system HipA family toxin Toxin
LPO_RS00340 68912..69151 - 240 WP_014840730.1 helix-turn-helix domain-containing protein Antitoxin
LPO_RS17365 69517..69881 + 365 Protein_65 protein LvrA -
LPO_RS17370 69991..70263 + 273 WP_172407380.1 hypothetical protein -
LPO_RS00350 70968..72365 - 1398 WP_027220326.1 hypothetical protein -
LPO_RS00355 72412..73020 - 609 WP_014840732.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 435 a.a.        Molecular weight: 49664.96 Da        Isoelectric Point: 7.7618

>T28038 WP_032832233.1 NC_018139:c68918-67614 [Legionella pneumophila subsp. pneumophila]
MVMRKLYILMNNELVGELTQDNAGGLSFSYVADWISKPHSRPVSLSLPLVNQRFSGEVVYNFFDNLLPDNPQIRARIQAR
FQAKSSRPFDLLALIGSDCVGAIQIVERIPQTQRLSIESHVVSEAEIARTLRSYQTSPLGMDKEDDEFRISIAGAQEKTA
FLYYQNEWHKPFGPTPTTHIFKLPIGYLPHQGIDLSESCENEHLCLLLASKFGLEVAKSKILQFEDEKVLVVERFDRKWS
RDNRYILRLPQEDLCQALGYSPNLKYQSDGGPGIKEIMQLLNGSQQPQKDRDEFFRAQVVYWCLGAIDAHAKNFSISIQP
QGGYQLTPLYDIISAYPIVEQKQLSFKKLKMAMALYGKNSHYKIDGIQKRHFIETAKYVQYSKIKAAQIFEQVIDRIDSA
IDEVSTQLPNHFPEKIADPIFKGMRAFKERMIST

Download         Length: 1305 bp

>T28038 NC_018139:c68918-67614 [Legionella pneumophila subsp. pneumophila]
ATGGTAATGCGTAAATTATACATATTAATGAACAATGAGCTCGTGGGGGAGCTTACCCAGGATAATGCAGGTGGTTTGAG
TTTTTCCTACGTTGCTGACTGGATTTCCAAACCACATTCGCGACCTGTATCTTTATCGTTGCCGTTAGTAAATCAAAGGT
TTTCAGGAGAAGTTGTATATAACTTTTTTGATAACTTACTTCCTGATAATCCGCAGATAAGAGCCAGAATTCAAGCTCGT
TTTCAGGCAAAATCATCGCGACCGTTTGATTTATTGGCGTTAATTGGCAGTGATTGTGTTGGTGCAATACAAATTGTTGA
ACGTATTCCTCAGACACAGCGCCTCAGCATTGAAAGTCACGTTGTCAGTGAGGCCGAGATAGCTCGTACTTTACGCTCTT
ACCAAACCTCACCACTGGGAATGGATAAAGAGGATGATGAGTTTAGAATCTCAATAGCCGGTGCTCAGGAAAAAACGGCT
TTTCTATATTACCAAAATGAATGGCATAAACCATTTGGACCTACACCAACAACTCACATATTCAAATTACCTATTGGATA
TTTACCACATCAAGGAATTGATTTAAGTGAGAGTTGTGAAAATGAGCATCTCTGTTTACTACTAGCCAGCAAATTTGGTT
TAGAGGTTGCAAAATCAAAAATCTTACAATTCGAAGATGAAAAGGTGCTGGTTGTCGAAAGATTTGATAGAAAATGGAGT
CGAGATAACCGTTATATACTCAGGTTACCGCAAGAAGACCTATGCCAAGCGTTGGGTTATTCACCAAATTTAAAATATCA
GTCAGATGGTGGCCCTGGTATTAAAGAAATTATGCAGCTACTTAATGGCTCACAGCAGCCTCAAAAAGATAGAGATGAAT
TTTTCAGAGCACAAGTTGTTTACTGGTGCCTTGGTGCTATTGATGCGCATGCCAAAAACTTCAGTATAAGTATACAACCA
CAAGGCGGTTACCAGCTCACCCCCTTATACGACATCATTTCAGCCTATCCTATCGTGGAACAAAAACAGCTATCCTTTAA
GAAATTGAAAATGGCAATGGCTTTATATGGTAAAAATAGTCATTACAAGATTGACGGTATTCAAAAAAGACACTTTATTG
AAACAGCAAAATACGTTCAATATTCTAAAATTAAAGCAGCTCAGATTTTTGAACAAGTGATTGACCGTATTGATTCTGCT
ATCGATGAGGTCTCAACACAATTACCAAACCACTTCCCAGAAAAGATTGCAGATCCAATCTTCAAAGGGATGAGAGCTTT
TAAGGAGCGAATGATATCCACATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9096.40 Da        Isoelectric Point: 5.0774

>AT28038 WP_014840730.1 NC_018139:c69151-68912 [Legionella pneumophila subsp. pneumophila]
MIISSAKDLALYLNDKRKQLKMSQSEVADLVGLKQDTISKFENSPDNSRIDTLFRILSALNLNMSLVEKDQKTHEEIEW

Download         Length: 240 bp

>AT28038 NC_018139:c69151-68912 [Legionella pneumophila subsp. pneumophila]
ATGATCATTAGCTCAGCAAAAGATTTAGCATTATATTTAAATGACAAACGCAAACAACTCAAAATGAGTCAATCTGAAGT
TGCCGATTTAGTCGGCTTAAAACAGGATACCATATCAAAGTTTGAAAATAGCCCTGATAATAGTCGAATTGATACCTTAT
TTAGAATATTGTCCGCCCTAAATTTAAATATGAGCCTTGTTGAAAAAGATCAAAAAACTCATGAAGAGATAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References