Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1938..2497 Replicon plasmid pAVS0947-B
Accession NZ_CP124462
Organism Escherichia coli strain AVS0947

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag QJP79_RS25085 Protein ID WP_000421257.1
Coordinates 2222..2497 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A827YCB8
Locus tag QJP79_RS25080 Protein ID WP_024186511.1
Coordinates 1938..2222 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP79_RS25075 (1) 1..1032 + 1032 WP_000907863.1 plasmid replication initiator RepA -
QJP79_RS25080 (1938) 1938..2222 + 285 WP_024186511.1 ribbon-helix-helix domain-containing protein Antitoxin
QJP79_RS25085 (2222) 2222..2497 + 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJP79_RS25090 (2572) 2572..3072 - 501 WP_024230392.1 hypothetical protein -
QJP79_RS25095 (3128) 3128..3730 - 603 WP_021560535.1 ProQ/FINO family protein -
QJP79_RS25100 (3906) 3906..4241 - 336 WP_242372526.1 hypothetical protein -
QJP79_RS25105 (4303) 4303..4944 - 642 WP_001473476.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..95665 95665


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T280375 WP_000421257.1 NZ_CP124462:2222-2497 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10502.95 Da        Isoelectric Point: 5.6558

>AT280375 WP_024186511.1 NZ_CP124462:1938-2222 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQIIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PMX5

Antitoxin

Source ID Structure
AlphaFold DB A0A827YCB8

References