Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 71994..72516 Replicon plasmid pKOX_R1
Accession NC_018107
Organism Klebsiella oxytoca E718

Toxin (Protein)


Gene name stbE Uniprot ID A0A7H0EVH6
Locus tag A225_RS28895 Protein ID WP_014839901.1
Coordinates 72232..72516 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A7H0EVH5
Locus tag A225_RS28890 Protein ID WP_014839900.1
Coordinates 71994..72242 (+) Length 83 a.a.

Genomic Context

A225_RS28860A225_RS32565A225_RS28870A225_RS28880A225_RS28890A225_RS28895A225_RS28900A225_RS28905A225_RS28885A225_RS33245A225_RS28915A225_RS28920A225_RS28925A225_RS34200
Location: 67174..67530 (357 bp)
Type: Others
Protein ID: WP_017901071.1
Location: 67903..68301 (399 bp)
Type: Others
Protein ID: WP_014839899.1
Location: 68437..69045 (609 bp)
Type: Others
Protein ID: WP_024266306.1
Location: 69589..70221 (633 bp)
Type: Others
Protein ID: WP_001567369.1
Location: 71994..72242 (249 bp)
Type: Antitoxin
Protein ID: WP_014839900.1
Location: 72232..72516 (285 bp)
Type: Toxin
Protein ID: WP_014839901.1
Location: 72707..73183 (477 bp)
Type: Others
Protein ID: WP_042934526.1
Location: 73189..73866 (678 bp)
Type: Others
Protein ID: WP_042934501.1
Location: 70250..71653 (1404 bp)
Type: Others
Protein ID: WP_001567368.1
Location: 73883..74602 (720 bp)
Type: Others
Protein ID: WP_042934502.1
Location: 74843..75445 (603 bp)
Type: Others
Protein ID: WP_014839902.1
Location: 75442..75962 (521 bp)
Type: Others
Protein ID: Protein_88
Location: 76043..76987 (945 bp)
Type: Others
Protein ID: WP_014839903.1
Location: 77050..77259 (210 bp)
Type: Others
Protein ID: WP_125316032.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A225_RS2886067174..67530+357WP_017901071.1hypothetical protein-
A225_RS3256567903..68301+399WP_014839899.1H-NS histone family protein-
A225_RS2887068437..69045+609WP_024266306.1DUF2913 family protein-
A225_RS2888069589..70221+633WP_001567369.1hypothetical protein-
A225_RS2888570250..71653-1404WP_001567368.1ISNCY-like element ISKpn21 family transposase-
A225_RS2889071994..72242+249WP_014839900.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
A225_RS2889572232..72516+285WP_014839901.1type II toxin-antitoxin system RelE/ParE family toxinToxin
A225_RS2890072707..73183+477WP_042934526.1hypothetical protein-
A225_RS2890573189..73866+678WP_042934501.1hypothetical protein-
A225_RS3324573883..74602-720WP_042934502.1cation:proton antiporter-
A225_RS2891574843..75445-603WP_014839902.1hypothetical protein-
A225_RS2892075442..75962-521Protein_88hypothetical protein-
A225_RS2892576043..76987-945WP_014839903.1DsbA family protein-
A225_RS3420077050..77259-210WP_125316032.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidcatA2 / aac(3)-IId / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 / blaCTX-M-3 / blaTEM-1B / ARR-3 / aac(6')-Ib-cr / fosA3 / blaSHV-12 / sul2 / aph(3'')-Ib / aph(6)-Id / qnrS1 / dfrA1 / aadA5-1..353865353865
-flankIS/Tn--70250..716531403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.46 Da        Isoelectric Point: 10.5831

>T28037 WP_014839901.1 NC_018107:72232-72516 [Klebsiella michiganensis E718]
MTYKLAFNESALKEWKKLGHTIREQFKKKLSERLQNPRVPAAQLHGGKDQYKIKLHGAGYRLVYSVNDEIVTVTVIGVGK
RNNDDIYNATRHRN

Download         Length: 285 bp

>T28037 NC_018107:72232-72516 [Klebsiella michiganensis E718]
ATGACCTATAAGTTAGCCTTCAATGAATCAGCTTTGAAAGAATGGAAAAAACTGGGTCATACTATTCGGGAGCAATTCAA
AAAGAAGCTTTCCGAACGGCTTCAGAACCCACGGGTGCCCGCAGCACAACTCCATGGAGGTAAAGACCAGTATAAAATAA
AGCTCCATGGCGCGGGTTACCGACTGGTTTACAGTGTCAACGATGAAATTGTGACGGTCACCGTAATTGGGGTGGGCAAA
CGCAACAATGATGATATCTACAACGCAACCCGACACAGAAATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9071.29 Da        Isoelectric Point: 3.8832

>AT28037 WP_014839900.1 NC_018107:71994-72242 [Klebsiella michiganensis E718]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMEMLEDQELGRIADERIGEDRIEVNID
DL

Download         Length: 249 bp

>AT28037 NC_018107:71994-72242 [Klebsiella michiganensis E718]
ATGGCATTTCAGGTTTTAACCACCACAGCAGCCAGCATTACAGAACTTAAACGTGACCCTATGGGTACCTTCAATGCAGG
AGAAGGTGCACCGGTAGCAATCCTGAATCGCAACGAACCCGCTTTTTACTGTGTACCACCAGCCCTGTATGCTCAGCTGA
TGGAAATGCTGGAAGATCAAGAGTTGGGGCGTATTGCTGATGAACGAATCGGTGAGGACCGAATCGAGGTCAACATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7H0EVH6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7H0EVH5

References