Detailed information of TA system TA280359

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3841292..3842981
• Replicon: chromosome
• Accession: NZ_CP124460
• Organism: Escherichia coli strain AVS0947

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP79_RS18640
• Protein ID: WP_000365807.1
• Coordinates: 3842061..3842981 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP79_RS18635
• Protein ID: WP_001295795.1
• Coordinates: 3841292..3842074 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP79_RS18630 (3837910)	3837910..3841008	-	3099	WP_000673070.1	type I restriction endonuclease	-
QJP79_RS18635 (3841292)	3841292..3842074	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP79_RS18640 (3842061)	3842061..3842981	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP79_RS18645 (3843146)	3843146..3843922	-	777	WP_000171155.1	site-specific integrase	-
QJP79_RS18650 (3844130)	3844130..3844465	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP79_RS18655 (3844692)	3844692..3844850	-	159	Protein_3640	integrase	-
QJP79_RS18660 (3844899)	3844899..3845084	+	186	WP_000146240.1	hypothetical protein	-
QJP79_RS18665 (3845299)	3845299..3845913	+	615	WP_001019923.1	YagU family protein	-
QJP79_RS18670 (3845984)	3845984..3846150	+	167	Protein_3643	tail fiber assembly protein	-
QJP79_RS18675 (3846162)	3846162..3846491	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP79_RS18680 (3846798)	3846798..3847508	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	3835042..3883197	48155
	-	inside	Genomic island	-	-	3835042..3845913	10871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280359 WP_000365807.1 NZ_CP124460:3842061-3842981 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280359 WP_001295795.1 NZ_CP124460:3841292-3842074 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0