Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2416389..2417189 Replicon chromosome
Accession NZ_CP124460
Organism Escherichia coli strain AVS0947

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJP79_RS11865 Protein ID WP_000342452.1
Coordinates 2416389..2416916 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJP79_RS11870 Protein ID WP_001277107.1
Coordinates 2416923..2417189 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP79_RS11840 (2411465) 2411465..2412232 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QJP79_RS11845 (2412229) 2412229..2413506 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJP79_RS11850 (2413503) 2413503..2414429 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJP79_RS11855 (2414477) 2414477..2415586 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJP79_RS11860 (2416009) 2416009..2416392 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJP79_RS11865 (2416389) 2416389..2416916 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJP79_RS11870 (2416923) 2416923..2417189 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJP79_RS11875 (2417338) 2417338..2418441 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJP79_RS11880 (2418712) 2418712..2419566 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJP79_RS11885 (2419811) 2419811..2420869 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
QJP79_RS11890 (2420862) 2420862..2421530 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T280354 WP_000342452.1 NZ_CP124460:c2416916-2416389 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT280354 WP_001277107.1 NZ_CP124460:c2417189-2416923 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References