Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 826674..827505 Replicon chromosome
Accession NZ_CP124460
Organism Escherichia coli strain AVS0947

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag QJP79_RS04315 Protein ID WP_000854815.1
Coordinates 827131..827505 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag QJP79_RS04310 Protein ID WP_001280918.1
Coordinates 826674..827042 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP79_RS04265 (821763) 821763..822509 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
QJP79_RS04270 (822592) 822592..822942 + 351 Protein_838 hypothetical protein -
QJP79_RS04275 (822958) 822958..823368 + 411 WP_000846703.1 hypothetical protein -
QJP79_RS04280 (823589) 823589..824407 + 819 WP_001542275.1 DUF932 domain-containing protein -
QJP79_RS04285 (824407) 824407..824652 + 246 WP_001164966.1 hypothetical protein -
QJP79_RS04290 (824746) 824746..825219 + 474 WP_001542276.1 antirestriction protein -
QJP79_RS04295 (825235) 825235..825711 + 477 WP_001186200.1 RadC family protein -
QJP79_RS04300 (825774) 825774..825995 + 222 WP_000692345.1 DUF987 domain-containing protein -
QJP79_RS04305 (826014) 826014..826658 + 645 WP_000086752.1 hypothetical protein -
QJP79_RS04310 (826674) 826674..827042 + 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QJP79_RS04315 (827131) 827131..827505 + 375 WP_000854815.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
QJP79_RS04320 (827502) 827502..827696 + 195 WP_000988600.1 DUF5983 family protein -
QJP79_RS04325 (827742) 827742..827822 + 81 Protein_849 hypothetical protein -
QJP79_RS04330 (828111) 828111..828191 - 81 WP_023441679.1 hypothetical protein -
QJP79_RS04335 (828440) 828440..828865 + 426 WP_000422741.1 transposase -
QJP79_RS04340 (828862) 828862..829212 + 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -
QJP79_RS04345 (829243) 829243..830856 + 1614 WP_000080195.1 IS66-like element ISEc23 family transposase -
QJP79_RS04350 (830899) 830899..831033 + 135 WP_059338447.1 EutP/PduV family microcompartment system protein -
QJP79_RS04355 (831134) 831134..831463 - 330 WP_000450409.1 DUF496 family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(19-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T280348 WP_000854815.1 NZ_CP124460:827131-827505 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp


Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT280348 WP_001280918.1 NZ_CP124460:826674-827042 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A066T988


Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References