Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 5159937..5160594 Replicon chromosome
Accession NC_018106
Organism Klebsiella oxytoca E718

Toxin (Protein)


Gene name cptA Uniprot ID J5U333
Locus tag A225_RS24040 Protein ID WP_004854060.1
Coordinates 5159937..5160347 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag A225_RS24045 Protein ID WP_004124953.1
Coordinates 5160328..5160594 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A225_RS24020 5155914..5157647 - 1734 WP_014226791.1 single-stranded-DNA-specific exonuclease RecJ -
A225_RS24025 5157653..5158366 - 714 WP_004854054.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A225_RS24030 5158389..5159285 - 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
A225_RS24035 5159407..5159928 + 522 WP_014226792.1 flavodoxin FldB -
A225_RS24040 5159937..5160347 - 411 WP_004854060.1 protein YgfX Toxin
A225_RS24045 5160328..5160594 - 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
A225_RS24050 5160839..5161822 + 984 WP_014226793.1 tRNA-modifying protein YgfZ -
A225_RS24055 5162016..5164814 + 2799 WP_014839506.1 transcriptional regulator DagR -
A225_RS24060 5164935..5165360 + 426 WP_004854067.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16106.97 Da        Isoelectric Point: 10.9455

>T28034 WP_004854060.1 NC_018106:c5160347-5159937 [Klebsiella michiganensis E718]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

>T28034 NC_018106:c5160347-5159937 [Klebsiella michiganensis E718]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAGTGGTTTTCGCTGCTGATGCACGGCGTGGTGGCGGC
GCTTGTGCTGCTGATGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCAGGGAGAAATCAAGCTGCTGATCGACTCCCGTCTGCGCTGGCAAAAGGCG
GAGTGGGATATCATCGGCACCCCGTGGGTGATTAACAGCGGAATGCTGCTGCGCCTGCGGAATACGGAAAACCAACGAAC
CCAGCATTTGTGGGTCGCGGCGGATAGCATGGACGCGGGAGAATGGCGAGACCTGCGTCGGCTGGTGTTGCTAAAACCGA
CGCAAGAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT28034 WP_004124953.1 NC_018106:c5160594-5160328 [Klebsiella michiganensis E718]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT28034 NC_018106:c5160594-5160328 [Klebsiella michiganensis E718]
ATGGACATTAACAATAAAGCCCGCATCCACTGGGCATGCCGTCGAGGTATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTCAGCGATGGCGATAAAGCGTTATTCATCCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGTTGATGAATCATGGCGAGCCGGCTGATGCAGAACTGCAGCGGATGGTAAAATTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References