Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4582680..4583480 Replicon chromosome
Accession NZ_CP124455
Organism Escherichia coli strain AVS0193

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJP76_RS22610 Protein ID WP_000342452.1
Coordinates 4582680..4583207 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJP76_RS22615 Protein ID WP_001277107.1
Coordinates 4583214..4583480 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP76_RS22585 (4577756) 4577756..4578523 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QJP76_RS22590 (4578520) 4578520..4579797 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJP76_RS22595 (4579794) 4579794..4580720 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJP76_RS22600 (4580768) 4580768..4581877 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJP76_RS22605 (4582300) 4582300..4582683 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJP76_RS22610 (4582680) 4582680..4583207 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJP76_RS22615 (4583214) 4583214..4583480 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJP76_RS22620 (4583629) 4583629..4584732 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJP76_RS22625 (4585003) 4585003..4585857 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJP76_RS22630 (4586102) 4586102..4587160 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
QJP76_RS22635 (4587153) 4587153..4587821 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T280334 WP_000342452.1 NZ_CP124455:c4583207-4582680 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT280334 WP_001277107.1 NZ_CP124455:c4583480-4583214 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References