Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1205444..1206062 Replicon chromosome
Accession NZ_CP124455
Organism Escherichia coli strain AVS0193

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP76_RS05775 Protein ID WP_001291435.1
Coordinates 1205444..1205662 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP76_RS05780 Protein ID WP_000344800.1
Coordinates 1205688..1206062 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP76_RS05740 (1200731) 1200731..1201303 + 573 WP_000779831.1 YbaY family lipoprotein -
QJP76_RS05745 (1201334) 1201334..1201645 - 312 WP_000409908.1 MGMT family protein -
QJP76_RS05755 (1202024) 1202024..1202377 + 354 WP_000878135.1 DUF1428 family protein -
QJP76_RS05760 (1202419) 1202419..1203969 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP76_RS05765 (1204133) 1204133..1204603 - 471 WP_000136192.1 YlaC family protein -
QJP76_RS05770 (1204719) 1204719..1205270 - 552 WP_000102539.1 maltose O-acetyltransferase -
QJP76_RS05775 (1205444) 1205444..1205662 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP76_RS05780 (1205688) 1205688..1206062 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP76_RS05785 (1206608) 1206608..1209757 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP76_RS05790 (1209780) 1209780..1210973 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T280317 WP_001291435.1 NZ_CP124455:c1205662-1205444 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT280317 WP_000344800.1 NZ_CP124455:c1206062-1205688 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References