Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 524668..525503 Replicon chromosome
Accession NZ_CP124455
Organism Escherichia coli strain AVS0193

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J2AEA6
Locus tag QJP76_RS02485 Protein ID WP_000854759.1
Coordinates 525126..525503 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag QJP76_RS02480 Protein ID WP_001295723.1
Coordinates 524668..525036 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP76_RS02450 (520687) 520687..521712 + 1026 Protein_471 autotransporter domain-containing protein -
QJP76_RS02455 (521783) 521783..521978 + 196 Protein_472 DUF905 family protein -
QJP76_RS02460 (522096) 522096..522914 + 819 WP_001234738.1 DUF932 domain-containing protein -
QJP76_RS02465 (523256) 523256..523729 + 474 WP_001350782.1 antirestriction protein -
QJP76_RS02470 (523745) 523745..524221 + 477 WP_001186775.1 RadC family protein -
QJP76_RS02475 (524284) 524284..524505 + 222 WP_000692345.1 DUF987 domain-containing protein -
QJP76_RS02480 (524668) 524668..525036 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QJP76_RS02485 (525126) 525126..525503 + 378 WP_000854759.1 TA system toxin CbtA family protein Toxin
QJP76_RS02490 (525500) 525500..525988 + 489 WP_000761690.1 DUF5983 family protein -
QJP76_RS02495 (526005) 526005..526181 + 177 WP_000839286.1 DUF957 domain-containing protein -
QJP76_RS02500 (526287) 526287..526436 + 150 Protein_481 hypothetical protein -
QJP76_RS02505 (526803) 526803..527108 + 306 Protein_482 helix-turn-helix domain-containing protein -
QJP76_RS02510 (527770) 527770..529392 + 1623 WP_001295726.1 Alw26I/Eco31I/Esp3I family type II restriction adenine-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14144.26 Da        Isoelectric Point: 7.3249

>T280314 WP_000854759.1 NZ_CP124455:525126-525503 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT280314 WP_001295723.1 NZ_CP124455:524668-525036 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2AEA6

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References