Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4213487..4214105 Replicon chromosome
Accession NZ_CP124442
Organism Escherichia coli strain AVS0196

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP94_RS20690 Protein ID WP_001291435.1
Coordinates 4213487..4213705 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP94_RS20695 Protein ID WP_000344800.1
Coordinates 4213731..4214105 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP94_RS20655 (4208774) 4208774..4209346 + 573 WP_000779831.1 YbaY family lipoprotein -
QJP94_RS20660 (4209377) 4209377..4209688 - 312 WP_000409908.1 MGMT family protein -
QJP94_RS20670 (4210067) 4210067..4210420 + 354 WP_000878135.1 DUF1428 family protein -
QJP94_RS20675 (4210462) 4210462..4212012 - 1551 Protein_4044 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP94_RS20680 (4212176) 4212176..4212646 - 471 WP_000136192.1 YlaC family protein -
QJP94_RS20685 (4212762) 4212762..4213313 - 552 WP_000102539.1 maltose O-acetyltransferase -
QJP94_RS20690 (4213487) 4213487..4213705 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP94_RS20695 (4213731) 4213731..4214105 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP94_RS20700 (4214651) 4214651..4217800 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP94_RS20705 (4217823) 4217823..4219016 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T280300 WP_001291435.1 NZ_CP124442:c4213705-4213487 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT280300 WP_000344800.1 NZ_CP124442:c4214105-4213731 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References