Detailed information of TA system TA280299

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4041068..4042757
• Replicon: chromosome
• Accession: NZ_CP124442
• Organism: Escherichia coli strain AVS0196

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP94_RS19865
• Protein ID: WP_000365807.1
• Coordinates: 4041837..4042757 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP94_RS19860
• Protein ID: WP_001295795.1
• Coordinates: 4041068..4041850 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP94_RS19855 (4037686)	4037686..4040784	-	3099	WP_000673070.1	type I restriction endonuclease	-
QJP94_RS19860 (4041068)	4041068..4041850	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP94_RS19865 (4041837)	4041837..4042757	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP94_RS19870 (4042922)	4042922..4043698	-	777	WP_000171155.1	site-specific integrase	-
QJP94_RS19875 (4043906)	4043906..4044241	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP94_RS19880 (4044468)	4044468..4044626	-	159	Protein_3886	integrase	-
QJP94_RS19885 (4044675)	4044675..4044860	+	186	WP_000146240.1	hypothetical protein	-
QJP94_RS19890 (4045075)	4045075..4045689	+	615	WP_001019923.1	YagU family protein	-
QJP94_RS19895 (4045760)	4045760..4045926	+	167	Protein_3889	tail fiber assembly protein	-
QJP94_RS19900 (4045938)	4045938..4046267	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP94_RS19905 (4046574)	4046574..4047284	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	4034818..4077350	42532

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280299 WP_000365807.1 NZ_CP124442:4041837-4042757 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280299 WP_001295795.1 NZ_CP124442:4041068-4041850 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0