Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3485696..3486291 Replicon chromosome
Accession NZ_CP124442
Organism Escherichia coli strain AVS0196

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QJP94_RS17160 Protein ID WP_000239579.1
Coordinates 3485941..3486291 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QJP94_RS17155 Protein ID WP_001223208.1
Coordinates 3485696..3485947 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP94_RS17145 (3481361) 3481361..3485140 + 3780 WP_000060945.1 autotransporter assembly complex protein TamB -
QJP94_RS17150 (3485143) 3485143..3485484 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QJP94_RS17155 (3485696) 3485696..3485947 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QJP94_RS17160 (3485941) 3485941..3486291 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QJP94_RS17165 (3486371) 3486371..3486901 - 531 WP_000055075.1 inorganic diphosphatase -
QJP94_RS17170 (3487211) 3487211..3488167 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QJP94_RS17175 (3488307) 3488307..3489809 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
QJP94_RS17180 (3489823) 3489823..3490845 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T280295 WP_000239579.1 NZ_CP124442:3485941-3486291 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT280295 WP_001223208.1 NZ_CP124442:3485696-3485947 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References