Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2516195..2516995 Replicon chromosome
Accession NZ_CP124442
Organism Escherichia coli strain AVS0196

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJP94_RS12560 Protein ID WP_000342452.1
Coordinates 2516195..2516722 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJP94_RS12565 Protein ID WP_001277107.1
Coordinates 2516729..2516995 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP94_RS12535 (2511271) 2511271..2512038 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QJP94_RS12540 (2512035) 2512035..2513312 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJP94_RS12545 (2513309) 2513309..2514235 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJP94_RS12550 (2514283) 2514283..2515392 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJP94_RS12555 (2515815) 2515815..2516198 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJP94_RS12560 (2516195) 2516195..2516722 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJP94_RS12565 (2516729) 2516729..2516995 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJP94_RS12570 (2517144) 2517144..2518247 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJP94_RS12575 (2518518) 2518518..2519372 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJP94_RS12580 (2519617) 2519617..2520675 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
QJP94_RS12585 (2520668) 2520668..2521336 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T280292 WP_000342452.1 NZ_CP124442:c2516722-2516195 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT280292 WP_001277107.1 NZ_CP124442:c2516995-2516729 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References