Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4225707..4226325 Replicon chromosome
Accession NZ_CP124436
Organism Escherichia coli strain AVS0790

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP66_RS20725 Protein ID WP_001291435.1
Coordinates 4225707..4225925 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP66_RS20730 Protein ID WP_000344800.1
Coordinates 4225951..4226325 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP66_RS20690 (4220994) 4220994..4221566 + 573 WP_000779831.1 YbaY family lipoprotein -
QJP66_RS20695 (4221597) 4221597..4221908 - 312 WP_000409908.1 MGMT family protein -
QJP66_RS20705 (4222287) 4222287..4222640 + 354 WP_000878135.1 DUF1428 family protein -
QJP66_RS20710 (4222682) 4222682..4224232 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP66_RS20715 (4224396) 4224396..4224866 - 471 WP_000136192.1 YlaC family protein -
QJP66_RS20720 (4224982) 4224982..4225533 - 552 WP_000102539.1 maltose O-acetyltransferase -
QJP66_RS20725 (4225707) 4225707..4225925 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP66_RS20730 (4225951) 4225951..4226325 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP66_RS20735 (4226871) 4226871..4230020 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP66_RS20740 (4230043) 4230043..4231236 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T280269 WP_001291435.1 NZ_CP124436:c4225925-4225707 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT280269 WP_000344800.1 NZ_CP124436:c4226325-4225951 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References