Detailed information of TA system TA280268

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4039777..4041466
• Replicon: chromosome
• Accession: NZ_CP124436
• Organism: Escherichia coli strain AVS0790

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP66_RS19850
• Protein ID: WP_000365807.1
• Coordinates: 4040546..4041466 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP66_RS19845
• Protein ID: WP_001295795.1
• Coordinates: 4039777..4040559 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP66_RS19840 (4036395)	4036395..4039493	-	3099	WP_000673070.1	type I restriction endonuclease	-
QJP66_RS19845 (4039777)	4039777..4040559	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP66_RS19850 (4040546)	4040546..4041466	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP66_RS19855 (4041631)	4041631..4042407	-	777	WP_000171155.1	site-specific integrase	-
QJP66_RS19860 (4042615)	4042615..4042950	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP66_RS19865 (4043177)	4043177..4043335	-	159	Protein_3883	integrase	-
QJP66_RS19870 (4043384)	4043384..4043569	+	186	WP_000146240.1	hypothetical protein	-
QJP66_RS19875 (4043784)	4043784..4044398	+	615	WP_001019923.1	YagU family protein	-
QJP66_RS19880 (4044469)	4044469..4044635	+	167	Protein_3886	tail fiber assembly protein	-
QJP66_RS19885 (4044647)	4044647..4044976	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP66_RS19890 (4045283)	4045283..4045993	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	4033527..4082458	48931

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280268 WP_000365807.1 NZ_CP124436:4040546-4041466 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280268 WP_001295795.1 NZ_CP124436:4039777-4040559 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0