Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2515686..2516486 Replicon chromosome
Accession NZ_CP124436
Organism Escherichia coli strain AVS0790

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJP66_RS12555 Protein ID WP_000342452.1
Coordinates 2515686..2516213 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJP66_RS12560 Protein ID WP_001277107.1
Coordinates 2516220..2516486 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP66_RS12530 (2510762) 2510762..2511529 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QJP66_RS12535 (2511526) 2511526..2512803 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJP66_RS12540 (2512800) 2512800..2513726 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJP66_RS12545 (2513774) 2513774..2514883 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJP66_RS12550 (2515306) 2515306..2515689 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJP66_RS12555 (2515686) 2515686..2516213 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJP66_RS12560 (2516220) 2516220..2516486 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJP66_RS12565 (2516635) 2516635..2517738 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJP66_RS12570 (2518009) 2518009..2518863 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJP66_RS12575 (2519108) 2519108..2520166 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
QJP66_RS12580 (2520159) 2520159..2520827 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T280261 WP_000342452.1 NZ_CP124436:c2516213-2515686 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT280261 WP_001277107.1 NZ_CP124436:c2516486-2516220 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References