Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 234603..236191 Replicon chromosome
Accession NZ_CP124436
Organism Escherichia coli strain AVS0790

Toxin (Protein)


Gene name hipA Uniprot ID A0A061YM43
Locus tag QJP66_RS01125 Protein ID WP_001125411.1
Coordinates 234603..235925 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A061YNW4
Locus tag QJP66_RS01130 Protein ID WP_001296076.1
Coordinates 235925..236191 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP66_RS01115 (232057) 232057..232767 - 711 WP_001195176.1 fimbria/pilus periplasmic chaperone -
QJP66_RS01120 (233129) 233129..233692 - 564 WP_001296074.1 type 1 fimbrial major subunit FimA -
QJP66_RS01125 (234603) 234603..235925 - 1323 WP_001125411.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QJP66_RS01130 (235925) 235925..236191 - 267 WP_001296076.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QJP66_RS01135 (236499) 236499..237257 + 759 WP_001286537.1 trans-aconitate 2-methyltransferase -
QJP66_RS01140 (237261) 237261..238175 - 915 WP_001296077.1 bestrophin family protein -
QJP66_RS01145 (238372) 238372..239823 - 1452 WP_000854638.1 tagaturonate reductase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-103)

Antitoxin

(18-69)


Sequences


Toxin        


Download         Length: 441 a.a.        Molecular weight: 49329.96 Da        Isoelectric Point: 7.7906

>T280250 WP_001125411.1 NZ_CP124436:c235925-234603 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAAEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHDRLSREYGIK

Download         Length: 1323 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9987.34 Da        Isoelectric Point: 4.9632

>AT280250 WP_001296076.1 NZ_CP124436:c236191-235925 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A061YM43


Antitoxin

Source ID Structure
AlphaFold DB A0A061YNW4

References