Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1402325..1402944 Replicon chromosome
Accession NC_018106
Organism Klebsiella oxytoca E718

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag A225_RS06450 Protein ID WP_004099646.1
Coordinates 1402325..1402543 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID H3N7X7
Locus tag A225_RS06455 Protein ID WP_004129911.1
Coordinates 1402570..1402944 (-) Length 125 a.a.

Genomic Context

A225_RS06420A225_RS06425A225_RS06435A225_RS06430A225_RS06440A225_RS06445A225_RS06450A225_RS06455A225_RS06460A225_RS06465
Location: 1398370..1398633 (264 bp)
Type: Others
Protein ID: WP_004848323.1
Location: 1398633..1398773 (141 bp)
Type: Others
Protein ID: WP_003859006.1
Location: 1399570..1401024 (1455 bp)
Type: Others
Protein ID: WP_014837606.1
Location: 1398770..1399468 (699 bp)
Type: Others
Protein ID: WP_014228203.1
Location: 1400999..1401469 (471 bp)
Type: Others
Protein ID: WP_014228205.1
Location: 1401596..1402162 (567 bp)
Type: Others
Protein ID: WP_014837607.1
Location: 1402325..1402543 (219 bp)
Type: Toxin
Protein ID: WP_004099646.1
Location: 1402570..1402944 (375 bp)
Type: Antitoxin
Protein ID: WP_004129911.1
Location: 1403424..1406570 (3147 bp)
Type: Others
Protein ID: WP_014228207.1
Location: 1406593..1407786 (1194 bp)
Type: Others
Protein ID: WP_004136054.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A225_RS064201398370..1398633+264WP_004848323.1type B 50S ribosomal protein L31-
A225_RS064251398633..1398773+141WP_003859006.1type B 50S ribosomal protein L36-
A225_RS064301398770..1399468-699WP_014228203.1GNAT family N-acetyltransferase-
A225_RS064351399570..1401024+1455WP_014837606.1PLP-dependent aminotransferase family protein-
A225_RS064401400999..1401469-471WP_014228205.1YlaC family protein-
A225_RS064451401596..1402162-567WP_014837607.1maltose O-acetyltransferase-
A225_RS064501402325..1402543-219WP_004099646.1hemolysin expression modulator HhaToxin
A225_RS064551402570..1402944-375WP_004129911.1Hha toxicity modulator TomBAntitoxin
A225_RS064601403424..1406570-3147WP_014228207.1multidrug efflux RND transporter permease subunit-
A225_RS064651406593..1407786-1194WP_004136054.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T28025 WP_004099646.1 NC_018106:c1402543-1402325 [Klebsiella michiganensis E718]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

>T28025 NC_018106:c1402543-1402325 [Klebsiella michiganensis E718]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGTTTACGACGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCCGATAATGAACTGGCGGTATTTTACTCTGCGGCCGATCATCGTCTTGCAGAGC
TGACGATGAATAAACTGTATGACAAGATCCCCCCTTCAGTCTGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT28025 WP_004129911.1 NC_018106:c1402944-1402570 [Klebsiella michiganensis E718]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQIDEYL
DDTFVLFSNYGINSADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT28025 NC_018106:c1402944-1402570 [Klebsiella michiganensis E718]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCACGGCTGGGTTAATGATCCAACCTCGGCTGTCAATCTTCAACTTAATGAATTGATCGAGC
ACATTGCCGCGTTTGCACTTAATTATAAAATTAAGTACGCAGAGGATAATAAGCTGATTACCCAGATTGACGAATATCTG
GATGACACTTTCGTCTTGTTCAGCAACTACGGCATTAACAGCGCAGATCTGCAGAAATGGCGTAAATCTGGCAATCGGTT
ATTCCGCTGCTTTGTCAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3H713

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3HD25

References