Detailed information of TA system TA028024

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-ArgA
• Location: 1163308..1164127
• Replicon: chromosome
• Accession: NC_018106
• Organism: Klebsiella oxytoca E718

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: A225_RS05325
• Protein ID: WP_004110819.1
• Coordinates: 1163308..1163565 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: A225_RS05330
• Protein ID: WP_014837489.1
• Coordinates: 1163576..1164127 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A225_RS05310	1158984..1159760	-	777	WP_004847986.1	Uxu operon transcriptional regulator	-
A225_RS05315	1159899..1161374	-	1476	WP_014228053.1	fructuronate reductase	-
A225_RS05320	1161448..1162632	-	1185	WP_014228054.1	mannonate dehydratase	-
A225_RS05325	1163308..1163565	+	258	WP_004110819.1	YjhX family toxin	Toxin
A225_RS05330	1163576..1164127	+	552	WP_014837489.1	N-acetyltransferase	Antitoxin
A225_RS05335	1164145..1165773	+	1629	WP_014837490.1	SAM-dependent methyltransferase	-
A225_RS34250	1165807..1165965	+	159	Protein_1040	hypothetical protein	-
A225_RS05345	1165962..1166377	+	416	Protein_1041	type II toxin-antitoxin system VapC family toxin	-
A225_RS05350	1166646..1167119	-	474	WP_032693194.1	hypothetical protein	-
A225_RS05355	1167430..1168062	-	633	WP_113705923.1	Zygote formation protein zyg1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (22-130)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T28024 WP_004110819.1 NC_018106:1163308-1163565 [Klebsiella michiganensis E718]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T28024 NC_018106:1163308-1163565 [Klebsiella michiganensis E718]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACATCCGCGATGCATC
AGGCCGCGTCACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCTTACCGCATCAATACCACCGGGCTGAATAACGTCCGCGCA
CAGCTGGACAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19902.64 Da
• Isoelectric Point: 6.4913

>AT28024 WP_014837489.1 NC_018106:1163576-1164127 [Klebsiella michiganensis E718]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGELIRHGIEQLKAMGSQAVFVLGHAAYYPRHGFEPGAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT28024 NC_018106:1163576-1164127 [Klebsiella michiganensis E718]
ATGACAAACCACAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCGATGACATTCTCGACGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCGATTTGCTCAACGATGAGAGCGCCTGCCCGACGCTATCGCTGCTGGCCA
GGCATAACGGAGAGGCGGTTGGGCATATTTTATTCACCCGGGCGACGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTGGCGGTGGTGCCGGAATACCAGGGCGCGGGCGTTGGCGGAGAGCTTATCCGGCACGGCATTGAGCA
GTTGAAAGCAATGGGAAGCCAGGCGGTATTTGTTCTGGGCCACGCCGCTTACTACCCCAGGCACGGGTTTGAGCCAGGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCGATTCCCGCGGCGCATAAAGCCTGCTGGATGCTGCAGCCGATTTCGTCT
CAGCCGCTGGGACGAACGGGCCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2