Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4442924..4443724 Replicon chromosome
Accession NZ_CP124429
Organism Escherichia coli strain AVS0051

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJP74_RS21740 Protein ID WP_000342452.1
Coordinates 4442924..4443451 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJP74_RS21745 Protein ID WP_001277107.1
Coordinates 4443458..4443724 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP74_RS21715 (4438000) 4438000..4438767 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QJP74_RS21720 (4438764) 4438764..4440041 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJP74_RS21725 (4440038) 4440038..4440964 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJP74_RS21730 (4441012) 4441012..4442121 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJP74_RS21735 (4442544) 4442544..4442927 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJP74_RS21740 (4442924) 4442924..4443451 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJP74_RS21745 (4443458) 4443458..4443724 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJP74_RS21750 (4443873) 4443873..4444976 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJP74_RS21755 (4445247) 4445247..4446101 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJP74_RS21760 (4446346) 4446346..4447404 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
QJP74_RS21765 (4447397) 4447397..4448065 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T280235 WP_000342452.1 NZ_CP124429:c4443451-4442924 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT280235 WP_001277107.1 NZ_CP124429:c4443724-4443458 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References