Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3766259..3766913 Replicon chromosome
Accession NZ_CP124429
Organism Escherichia coli strain AVS0051

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QJP74_RS18320 Protein ID WP_000244765.1
Coordinates 3766259..3766666 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QJP74_RS18325 Protein ID WP_000354050.1
Coordinates 3766647..3766913 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP74_RS18300 (3762216) 3762216..3763949 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
QJP74_RS18305 (3763955) 3763955..3764665 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJP74_RS18310 (3764690) 3764690..3765586 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QJP74_RS18315 (3765698) 3765698..3766219 + 522 WP_001055874.1 flavodoxin FldB -
QJP74_RS18320 (3766259) 3766259..3766666 - 408 WP_000244765.1 protein YgfX Toxin
QJP74_RS18325 (3766647) 3766647..3766913 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QJP74_RS18330 (3767156) 3767156..3768136 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
QJP74_RS18335 (3768213) 3768213..3768872 - 660 WP_000250275.1 hemolysin III family protein -
QJP74_RS18340 (3769036) 3769036..3769347 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QJP74_RS18345 (3769392) 3769392..3770825 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T280231 WP_000244765.1 NZ_CP124429:c3766666-3766259 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT280231 WP_000354050.1 NZ_CP124429:c3766913-3766647 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References