Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2291860..2293448 | Replicon | chromosome |
Accession | NZ_CP124429 | ||
Organism | Escherichia coli strain AVS0051 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | A0A061YM43 |
Locus tag | QJP74_RS11255 | Protein ID | WP_001125411.1 |
Coordinates | 2291860..2293182 (-) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | A0A061YNW4 |
Locus tag | QJP74_RS11260 | Protein ID | WP_001296076.1 |
Coordinates | 2293182..2293448 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QJP74_RS11245 (2289314) | 2289314..2290024 | - | 711 | WP_001195176.1 | fimbria/pilus periplasmic chaperone | - |
QJP74_RS11250 (2290386) | 2290386..2290949 | - | 564 | WP_001296074.1 | type 1 fimbrial major subunit FimA | - |
QJP74_RS11255 (2291860) | 2291860..2293182 | - | 1323 | WP_001125411.1 | type II toxin-antitoxin system serine/threonine protein kinase toxin HipA | Toxin |
QJP74_RS11260 (2293182) | 2293182..2293448 | - | 267 | WP_001296076.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
QJP74_RS11265 (2293756) | 2293756..2294514 | + | 759 | WP_001286537.1 | trans-aconitate 2-methyltransferase | - |
QJP74_RS11270 (2294518) | 2294518..2295432 | - | 915 | WP_001296077.1 | bestrophin family protein | - |
QJP74_RS11275 (2295629) | 2295629..2297080 | - | 1452 | WP_000854638.1 | tagaturonate reductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49329.96 Da Isoelectric Point: 7.7906
>T280224 WP_001125411.1 NZ_CP124429:c2293182-2291860 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAAEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHDRLSREYGIK
MPKLVTWMNNQRVGELTKLANGAHTFKYAAEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHDRLSREYGIK
Download Length: 1323 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A061YM43 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A061YNW4 |