Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1136862..1137480 Replicon chromosome
Accession NZ_CP124429
Organism Escherichia coli strain AVS0051

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP74_RS05405 Protein ID WP_001291435.1
Coordinates 1136862..1137080 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP74_RS05410 Protein ID WP_000344800.1
Coordinates 1137106..1137480 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP74_RS05370 (1132149) 1132149..1132721 + 573 WP_000779831.1 YbaY family lipoprotein -
QJP74_RS05375 (1132752) 1132752..1133063 - 312 WP_000409908.1 MGMT family protein -
QJP74_RS05385 (1133442) 1133442..1133795 + 354 WP_000878135.1 DUF1428 family protein -
QJP74_RS05390 (1133837) 1133837..1135387 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP74_RS05395 (1135551) 1135551..1136021 - 471 WP_000136192.1 YlaC family protein -
QJP74_RS05400 (1136137) 1136137..1136688 - 552 WP_000102539.1 maltose O-acetyltransferase -
QJP74_RS05405 (1136862) 1136862..1137080 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP74_RS05410 (1137106) 1137106..1137480 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP74_RS05415 (1138026) 1138026..1141175 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP74_RS05420 (1141198) 1141198..1142391 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T280218 WP_001291435.1 NZ_CP124429:c1137080-1136862 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT280218 WP_000344800.1 NZ_CP124429:c1137480-1137106 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References