Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 531549..532384 Replicon chromosome
Accession NZ_CP124429
Organism Escherichia coli strain AVS0051

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J2AEA6
Locus tag QJP74_RS02505 Protein ID WP_000854759.1
Coordinates 532007..532384 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag QJP74_RS02500 Protein ID WP_001295723.1
Coordinates 531549..531917 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP74_RS02475 (528664) 528664..528859 + 196 Protein_476 DUF905 family protein -
QJP74_RS02480 (528977) 528977..529795 + 819 WP_001234738.1 DUF932 domain-containing protein -
QJP74_RS02485 (530137) 530137..530610 + 474 WP_001350782.1 antirestriction protein -
QJP74_RS02490 (530626) 530626..531102 + 477 WP_001186775.1 RadC family protein -
QJP74_RS02495 (531165) 531165..531386 + 222 WP_000692345.1 DUF987 domain-containing protein -
QJP74_RS02500 (531549) 531549..531917 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QJP74_RS02505 (532007) 532007..532384 + 378 WP_000854759.1 TA system toxin CbtA family protein Toxin
QJP74_RS02510 (532381) 532381..532869 + 489 WP_000761690.1 DUF5983 family protein -
QJP74_RS02515 (532886) 532886..533062 + 177 WP_000839286.1 DUF957 domain-containing protein -
QJP74_RS02520 (533168) 533168..533317 + 150 Protein_485 hypothetical protein -
QJP74_RS02525 (533684) 533684..533989 + 306 Protein_486 helix-turn-helix domain-containing protein -
QJP74_RS02530 (534651) 534651..536273 + 1623 WP_001295726.1 Alw26I/Eco31I/Esp3I family type II restriction adenine-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimE 517854..554956 37102


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14144.26 Da        Isoelectric Point: 7.3249

>T280214 WP_000854759.1 NZ_CP124429:532007-532384 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT280214 WP_001295723.1 NZ_CP124429:531549-531917 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2AEA6

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References