Detailed information of TA system TA028020

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 1318099..1318685
• Replicon: chromosome
• Accession: NC_018089
• Organism: Streptococcus mutans GS-5

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: SMUGS5_RS06285
• Protein ID: WP_002265423.1
• Coordinates: 1318494..1318685 (-)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A090B427
• Locus tag: SMUGS5_RS06280
• Protein ID: WP_002279856.1
• Coordinates: 1318099..1318476 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMUGS5_RS06270	1314882..1315166	-	285	WP_002262720.1	helix-turn-helix transcriptional regulator	-
SMUGS5_RS06275	1315481..1316374	+	894	WP_002262721.1	LexA family transcriptional regulator IrvR	-
SMUGS5_RS06280	1318099..1318476	-	378	WP_002279856.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
SMUGS5_RS06285	1318494..1318685	-	192	WP_002265423.1	type II toxin-antitoxin system HicA family toxin	Toxin
SMUGS5_RS06290	1318782..1319444	-	663	WP_002279857.1	type II-A CRISPR-associated protein Csn2	-
SMUGS5_RS06295	1319434..1319778	-	345	WP_002263547.1	CRISPR-associated endonuclease Cas2	-
SMUGS5_RS06300	1319775..1320641	-	867	WP_002279858.1	type II CRISPR-associated endonuclease Cas1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-106)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7177.52 Da
• Isoelectric Point: 10.7089

>T28020 WP_002265423.1 NC_018089:c1318685-1318494 [Streptococcus mutans GS-5]
MPLTGKELARLAINNGWEEVRVRGSHHHFKKDGVPYIVTIPIHGNKVLKIGLEKKLLRDLNLL

Nucleotide

• Length: 192 bp

>T28020 NC_018089:c1318685-1318494 [Streptococcus mutans GS-5]
TTGCCATTAACAGGGAAAGAATTAGCTAGATTAGCGATAAACAATGGATGGGAAGAAGTTCGGGTGAGAGGAAGTCATCA
TCATTTCAAGAAAGATGGAGTACCTTATATTGTGACGATTCCCATTCATGGAAATAAAGTGCTTAAAATTGGTCTTGAAA
AGAAACTCTTAAGGGATTTAAATTTATTATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14250.28 Da
• Isoelectric Point: 4.5540

>AT28020 WP_002279856.1 NC_018089:c1318476-1318099 [Streptococcus mutans GS-5]
MLKTYPAIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGLVLPISSDIQKISVEDGFATMIQADP
SPYLKNNKAIRKNVTVPEWLIRLADRDRVNYSEVLTKALEKKLQL

Nucleotide

• Length: 378 bp

>AT28020 NC_018089:c1318476-1318099 [Streptococcus mutans GS-5]
ATGTTAAAAACATATCCTGCAATTTTTCATAAGGAAGAGGAAGGATATTGGGTTGAATTTCCTGAATTTGGCGGTGGTAC
GCAAGGGGAAGATTTGGAAGAAGCCATGAAGAACGCTCGTCAGATGTTAGAAAGTGTGTTGGCATCTTATCTTGATGAAG
GGTTGGTTCTACCCATTTCAAGCGATATTCAGAAAATATCTGTTGAAGATGGTTTTGCGACCATGATTCAAGCTGATCCT
AGTCCTTATCTCAAAAATAACAAAGCTATTCGGAAAAATGTTACCGTGCCTGAGTGGTTGATACGATTAGCAGACCGTGA
CCGAGTAAATTATTCTGAAGTATTAACAAAGGCTTTGGAAAAGAAACTACAATTATAA

Structures

Antitoxin

• AlphaFold DB: A0A090B427